Research Article
Diagnosis and Prognosis of Sepsis Based on Use of Cytokines, Chemokines, and Growth Factors
Table 2
Comparison of cytokines, chemokines, and growth factors between control and sepsis groups.
| | Molecules (pg/mL) | Control () | Sepsis () | Bonferroni | | Mean | SD | Mean | SD | correction ( value) |
| | Cytokines | | | | | | | IFN-α | 0.05 | 0.48 | 7.82 | 63.18 | NS | | IFN-γ | 0.00 | 0.00 | 20.82 | 142.23 | <0.05 | | IL-1RA | 216.65 | 348.15 | 17564.94 | 32132.31 | NS | | IL-1α | 2.18 | 7.23 | 18.02 | 55.50 | <0.05 | | IL-1β | 0.45 | 1.62 | 3.26 | 7.92 | NS | | IL-2 | 10.57 | 10.26 | 17.40 | 24.54 | NS | | IL-4 | 0.00 | 0.00 | 8.88 | 33.03 | <0.05 | | IL-5 | 0.00 | 0.00 | 4.95 | 18.71 | <0.05 | | IL-6 | 4.72 | 17.12 | 1931.93 | 4803.73 | NS | | IL-7 | 2.21 | 1.94 | 6.42 | 7.94 | NS | | IL-8 | 12.43 | 36.10 | 310.08 | 945.84 | <0.05 | | IL-9 | 0.00 | 0.00 | 13.63 | 96.09 | <0.05 | | IL-10 | 0.07 | 0.44 | 88.55 | 321.44 | <0.05 | | IL-12p70 | 0.19 | 1.72 | 0.36 | 2.39 | <0.05 | | IL-13 | 0.48 | 1.94 | 6.77 | 19.59 | <0.05 | | IL-15 | 10.35 | 12.49 | 17.45 | 31.95 | NS | | IL-17A | 1.04 | 2.44 | 7.05 | 16.59 | <0.05 | | IL-18 | 1.50 | 5.51 | 53.49 | 85.48 | <0.05 | | IL-21 | 5.12 | 19.14 | 102.14 | 460.64 | <0.05 | | IL-22 | 10.06 | 45.38 | 494.81 | 2857.13 | <0.05 | | IL-23 | 2.11 | 15.13 | 58.33 | 272.71 | <0.05 | | IL-27 | 0.99 | 8.77 | 46.00 | 201.57 | <0.05 | | IL-31 | 0.65 | 5.75 | 30.31 | 158.07 | <0.05 | | LIF | 6.22 | 7.71 | 45.19 | 131.78 | NS | | GM-CSF (CSF2) | 0.00 | 0.00 | 6.71 | 40.87 | NS | | SCF (KITLG) | 11.12 | 8.92 | 28.70 | 34.10 | <0.05 | | TNF-α (LTA) | 1.64 | 5.73 | 4.43 | 14.96 | NS | | TNF-β (LTB) | 0.00 | 0.00 | 9.48 | 72.78 | <0.05 | | Chemokines | | | | | | | CCL2 (MCP-1) | 65.96 | 48.52 | 811.06 | 1335.39 | <0.05 | | CCL3 (MIP-1α) | 16.07 | 21.33 | 22.90 | 36.19 | <0.05 | | CCL4 (MIP-1β) | 264.96 | 163.90 | 729.02 | 1870.12 | NS | | CCL5 (RANTES) | 185.57 | 185.20 | 604.49 | 565.59 | NS | | CCL11 (eotaxin) | 112.30 | 49.84 | 126.04 | 100.40 | <0.05 | | CXCL1 (GRO-α) | 1.81 | 11.51 | 82.01 | 301.55 | <0.05 | | CXCL10 (IP-10) | 31.98 | 18.56 | 234.04 | 549.42 | <0.05 | | CXCL12 (SDF-1) | 691.12 | 207.49 | 1325.08 | 1204.70 | NS | | Growth factors | | | | | | | BDNF | 262.82 | 226.55 | 604.23 | 589.93 | <0.05 | | EGF | 43.62 | 30.99 | 35.90 | 58.03 | <0.05 | | FGF-2 | 0.08 | 0.74 | 28.01 | 110.35 | <0.05 | | HGF | 184.27 | 142.38 | 1111.45 | 1570.22 | <0.05 | | NGF | 7.46 | 15.35 | 31.18 | 50.72 | <0.05 | | PDGF-BB | 119.25 | 132.24 | 565.48 | 1157.25 | <0.05 | | PLGF-1 | 141.03 | 86.31 | 237.79 | 271.32 | <0.05 | | VEGF-A | 204.48 | 212.45 | 831.87 | 1088.99 | <0.05 | | VEGF-D (FIGF) | 6.84 | 8.46 | 27.58 | 28.21 | <0.05 |
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IFN: interferon; IL: interleukin; LIF: leukemia inhibitory factor; TNF: tumor necrosis factor; CCL: CC motif chemokine ligand; CXCL: CXC motif ligand; BDNF: brain-derived neurotrophic factor; EGF: epidermal growth factor; FGF: fibroblast growth factor; GM-CSF: granulocyte macrophage colony stimulating factor; HGF: hepatocyte growth factor; NGF: nerve growth factor; PDGF: platelet-derived growth factor; PLGF: placental growth factor; SCF: stem cell factor; VEGF: vascular endothelial growth factor.
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