Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer

Figure 3

(a) Mean staining results of mTOR, phosphorylated mTOR, and 4E-BP1 in (A) tissue samples located in the tumor center, (B) in the tumor invasion front, (C) benign tissue samples adjacent to the tumor invasion front, and (D) tumor-distant remote tissue. Post hoc analyses for each comparison were performed with the Bonferroni test. (b) Mean staining results of (tumor tissue samples A, see text) for mTOR, phosphorylated mTOR, and 4E-BP1 according to Gleason score and pathological stage in our own cohort. (c) Protein levels according to the reverse phase protein array of mTOR and 4E-BP1 according to Gleason score and pathological stage in the TGCA cohort.

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