Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer

Table 2

Expression patterns of mTOR, phosphorylated mTOR, and 4E-BP1 (A) the tissue from the tumor center, (B) tumor tissue of the tumor invasion front tumor, (C) benign tissue adjacent to the tumor, and (D) benign tissue distant from the tumor.

Molecular markers	A	B	C	D	value between all groups
mTOR, mean (SD)	9.1 (2.9)	8.8 (3.3)	5.0 (3.8)	6.8 (3.7)	<0.01
Phosphorylated mTOR, mean (SD)	7.4 (3.5)	7.2 (3.5)	2.0 (2.6)	4.6 (3.5)	<0.01
4E-BP1, mean (SD)	8.0 (3.3)	7.6 (3.2)	2.6 (2.0)	3.1 (2.1)	<0.01

ANOVA test. mTOR = mammalian target of rapamycin; 4E-BP1 = 4 eukaryotic-binding protein 1.