Cardiovascular Insufficiency, Abdominal Sepsis, and Patients’ Age Are Associated with Decreased Paraoxonase-1 (PON1) Activity in Critically Ill Patients with Multiple Organ Dysfunction Syndrome (MODS)

Table 1

Characteristics of critically ill patients with MODS.

	Severe sepsis ()	Septic shock ()	value
Gender, F/M	6/4	12/13	0.527^F
Age (yrs. (range))	50.5 (18-72)	55 (21-91)	0.189^M
Creatinine (mg%)	1.71 (0.92-3.19)	1.59 (1.13-2.22)	0.814^t
Bilirubin (mg%)	0.98 (0.68-1.43)	1.03 (0.78-1.37)	0.845^t
PLT (×10^3/mm^3)	99 (65-134)	155 (99-212)	0.083^W
WBC (×10^3/mm^3)	12.1 (5.4-18.8)	16.9 (10.2-23.6)	0.374^t
CRP (mg/L)	220.6 (105-336)	269.4 (201-338)	0.430^t
PCT (μg/L)	2.55 (0.69-9.41)	6.96 (3.14-15.46)	0.168^t
IL-6 (ng/L)	73.7 (31.2-174.1)	630 (259-1536)	0.006^t
LBP (mg/L)	44.2 (26.8-54.3)	47.7 (42-51.4)	0.361^M
ICU stay (days (range))	7 (4-125)	13 (6-180)	0.018^M
Survivors/nonsurvivors ()	8/2	10/15	0.035^F
APACHE II (range)	20 (14-31)	24 (18-28)	0.622^M
SOFA (range)	6 (4.5-10)	10 (7-12)	0.092^M
Infection site ()			0.596
Abdominal	2	7
Pulmonary	5	13
Blood	0	1
Other	3	3
Unknown	0	1
Number of organ failures ()			0.058
2	4	3
3	3	7
4	2	9
5	1	4
6	0	2
Organ/system dysfunction ( (%))
Cardiovascular	2 (20)	25 (100)	<0.001^F
Pulmonary	8 (80)	25 (100)	0.076^F
Renal	6 (60)	12 (48)	0.711^F
Hepatic	2 (20)	3 (12)	0.610^F
Hematologic	6 (60)	14 (56)	1^F
Metabolic	4 (40)	16 (64)	0.266^F
CNS	2 (20)	0	0.076^F
Pathogen ()			0.243
Gram-positive	2	8
Gram-negative	1	6
Mixed	1	5
Unknown	6	6

F, Fisher's exact test; M, Mann-Whitney U test; t, t-test for independent samples; W, Welch test; , Ch-square test.