ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population

Table 11

Association of ABCB1 polymorphisms and drug resistance in generalized and focal epileptic subgroups.

Generalized		Drug-resistant patients ()		Drug-responsive patients ()		ORs	95% CI	value	^2
			%		%
ABCB1 C1236T genotypes	TT vs. CC+CT	23	54.762	2	6.061	18.763	3.968-88.729	≤0.001	19.720
	TT vs. CC	23	82.143	2	14.286	27.600	4.644-164.027	≤0.001	17.840
ABCB1 G2677T genotypes	TT vs. GG+GT	24	57.143	4	12.121	7.250	2.209-23.800	0.001	12.410
	TT vs. GT	24	68.571	4	12.903	14.727	4.137-52.423	≤0.001	20.860
ABCB1 C3435T genotypes	TT vs. CC+CT	26	61.905	3	9.091	16.250	4.254-62.079	≤0.001	21.740
	TT vs. CC	26	72.222	3	16.667	13.000	3.086-54.773	0.001	14.900
	TT vs. CT	26	81.250	3	16.667	21.667	4.717-99.530	≤0.001	19.720
ABCB1 C1236T alleles	TT vs. CT	23	61.162	2	9.524	15.607	3.147-77.409	0.001	15.140
	T vs. C	60	71.429	23	34.848	4.674	2.337-9.348	≤0.001	20.010
ABCB1 G2677T alleles	T vs. G	59	70.238	35	53.030	2.090	1.067-4.096	0.032	4.680
ABCB1 C1236T-G2677T	TG	9	21.429	1	3.030	8.727	1.045-72.888	0.045	5.410
	TT	14	33.333	1	3.030	16.000	1.977-129.518	0.009	10.610
ABCB1 G2677T-C3435T	GT	13	30.952	3	9.091	4.483	1.156-17.382	0.030	5.260
	TT	12	28.571	0	0	27.459	1.559-483.811	0.024	11.220
ABCB1 C1236T-C3435T	TC	10	23.810	2	6.061	4.844	0.981-23.908	0.053	4.330
	TT	13	30.952	0	0	30.661	1.746-538.489	0.019	12.360
Focal		Drug-resistant patients ()		Drug-responsive patients ()		ORs	95% CI	value	^2
			%		%
ABCB1 C3435T alleles	T vs. C	5	83.333	11	32.353	10.455	1.087-100.599	0.042	5.520
ABCB1 C1236T-C3435T	CT	2	66.667	1	5.882	32.000	1.389-737.501	0.030	7.390

Values ( and %). ORs: odds ratio; 95% CI: confidence interval; significant value ≤ 0.05; ²: chi-square.