ABCB1 Polymorphisms and Drug-Resistant Epilepsy in a Tunisian Population

Table 13

Association of ABCB1 polymorphisms and drug resistance in unknown and genetic epileptic subgroups.

Genetic		Drug-resistant patients ()		Drug-responsive patients ()		ORs	95% CI	value	^2
			%		%
ABCB1 C1236T genotypes	TT vs. CC+CT	14	58.333	0	0	20.714	1.062-404.123	0.046	7.450
	TT vs. CT	14	70	0	0	24.539	1.175-512.647	0.039	7.950
ABCB1 G2677T genotypes	TT vs. GT	12	60	0	0	19.118	0.947-386.136	0.054	6.690
ABCB1 C3435T genotypes	TT vs. CC+CT	16	66.667	1	14.286	12.000	1.226-117.417	0.033	6
	TT vs. CT	16	100	1	20	99.000	3.418-2867.633	0.008	15.810
ABCB1 C1236T alleles	T vs. C	33	68.750	5	35.714	3.960	1.132-13.850	0.031	4.990
Unknown		Drug-resistant patients ()		Drug-responsive patients ()		ORs	95% CI	value	^2
			%		%
ABCB1 G2677T genotypes	GG vs. GT+TT	6	23.077	1	3.226	9.000	1.006-80.525	0.049	5.170
	TT vs. GG+GT	15	57.692	5	16.129	7.091	2.066-24.344	0.002	10.730
ABCB1 C3435T genotypes	TT vs. CC	14	82.353	3	16.667	23.333	4.021-135.391	≤0.001	15.100
ABCB1 C3435T alleles	T vs. C	37	71.154	19	30.645	5.583	2.491-12.513	≤0.001	18.570
ABCB1 C1236T-G2677T	TT	6	23.077	1	3.226	9.000	1.006-80.525	0.049	5.170
ABCB1 G2677T-C3435T	TT	6	23.077	0	0	19.976	1.067-374.011	0.045	8
ABCB1 C1236T-C3435T	CT	8	30.769	2	6.452	6.444	1.229-33.805	0.028	5.780
	TT	6	23.077	1	3.226	9.000	1.006-80.525	0.049	5.170

Values ( and %). ORs: odds ratio; 95% CI: confidence interval; significant value ≤ 0.05; ²: chi-square.