The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

Table 4

Evaluation of traditional inflammatory biomarkers and VCS parameters in indicating sepsis of patients with cirrhosis by ROC (, ).

Parameter or biomarkers	AUC (%)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Cutoff value (positive cases)^†
PCT (ng/mL)	90.1	77.8	93	85.7	88.6	0.51 (42)
IL-6 (pg/mL)	71.8	81.5	93	86.3	90.3	465 (44)
sCD163 (mg/mL)	84.4	83.3	76	65.2	89.4	0.97 (45)
MNV	71.6	57.4	86	68.9	78.9	143.88 (31)
MMV	79.3	75.9	73	60.3	84.9	170.33 (41)
MMS	62.6	61.1	84	67.3	80.0	92.17 (33)
MLV	67.5	90.7	37	43.8	88.1	81.96 (49)
NDW	71.7	88.9	44	46.2	88.0	17.78 (48)
MDW	76.7	75.9	76	63.1	85.4	19.19 (41)
MMV and MDW	88.6	90.7	95	90.7	95.0

AUC: area under the curve; NPV: negative predictive value; PPV: positive predictive value; PCT: procalcitonin; IL-6: interleukin-6; sCD163: soluble hemoglobin scavenger receptor; ROC: receiver operating characteristic. ^†The positive cases were calculated by a cutoff value from respective ROC curves.