The Leukocyte VCS Parameters Compared with Procalcitonin, Interleukin-6, and Soluble Hemoglobin Scavenger Receptor sCD163 for Prediction of Sepsis in Patients with Cirrhosis

Table 5

Evaluation of traditional inflammatory biomarkers and VCS parameters in indicating infection of patients with cirrhosis by ROC (, ).

Parameter or biomarkers	AUC (%)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Cutoff value (positive cases)^†
PCT (ng/mL)	89.2	86.32	56	65.08	81.15	0.31 (82)
IL-6 (pg/mL)	83.9	70.53	84	80.72	75.00	392 (67)
sCD163 (mg/mL)	87.7	98.47	45	60.71	81.82	0.61 (85)
MNV	73.3	90.53	38	58.11	84.44	137.81 (86)
MMS	76.3	77.89	72	72.55	77.42	89.53 (74)
MLV	69.4	97.89	27	56.02	93.10	80.88 (93)
MNV and MMS	82.6	86.32	92	82.00	87.62

AUC: area under the curve; NPV: negative predictive value; PPV: positive predictive value; PCT: procalcitonin; IL-6: interleukin-6; sCD163: soluble hemoglobin scavenger receptor; ROC: receiver operating characteristic. ^†The positive cases were calculated by a cutoff value from respective ROC curves.