Bioinformatics Analysis of Potential Key Genes in Trastuzumab-Resistant Gastric Cancer
Table 1
Functional and pathway enrichment analyses of the DEGs in trastuzumab-resistant gastric cancer.
Category
Description
Count
value
GO function
BP
Type I interferon signaling pathway
13
1.04
BP
Negative regulation of viral genome replication
10
2.46
BP
Cell proliferation
23
5.99
BP
Positive regulation of apoptotic process
18
2.51
BP
Extracellular matrix organization
13
1.92
CC
Extracellular exosome
90
1.28
CC
Intermediate filament
11
2.26
CC
Cytoplasm
122
3.98
CC
Proteinaceous extracellular matrix
16
5.65
CC
Basolateral plasma membrane
13
5.98
MF
Structural molecule activity
17
8.93
MF
Calcium ion binding
27
4.52
MF
Protein homodimerization activity
26
1.31
MF
2-5-oligoadenylate synthetase activity
3
1.83
MF
Fibronectin binding
4
1.06
KEGG pathway
hsa05200
Pathways in cancer
18
5.47
hsa04550
Signaling pathways regulating pluripotency of stem cells
8
1.22
hsa05166
HTLV-I infection
11
1.56
hsa04512
ECM-receptor interaction
6
1.91
hsa05230
Central carbon metabolism in cancer
5
2.68
Note: top five terms were selected according to value. Abbreviation: DEGs: differentially expressed genes; GO: gene ontology; BP: biological process; CC: cellular component; MF: molecular function; HTLV-I: human T lymphocyte virus-I; ECM: extracellular matrix.
