Prognostic Significance of Serum Uric Acid and Gamma-Glutamyltransferase in Patients with Advanced Gastric Cancer

Table 2

Univariate analysis of primary cohort ().

			OS			PFS
			HR	95% CI		HR	95% CI
Sex	(Male vs Female)	0.599	1.113	0.746-1.663	0.117	1.371	0.924-2.033
Age		0.001	1.030	1.013-1.048	0.403	1.007	0.991-1.022
NLR		0.021	1.025	1.004-1.047	0.036	1.029	1.002-1.057
PLR		0.014	1.001	1.000-1.002	0.170	1.001	1.000-1.002
LMR		0.965	1.000	0.979-1.023	0.610	0.994	0.971-1.018
D-D		0.153	1.000	1.000-1.000	0.019	1.000	1.000-1.000
FIB		0.265	1.053	0.962-1.152	0.019	1.098	1.016-1.187
ALB		0.021	0.962	0.931-0.994	0.102	0.975	0.945-1.005
Cholesterol		0.346	0.933	0.807-1.078	0.560	0.963	0.847-1.094
Triglyceride		0.420	1.089	0.885-1.341	0.994	1.001	0.821-1.220
HDL		<0.001	0.328	0.181-0.594	0.019	0.542	0.324-0.906
GGT		<0.001	1.006	1.003-1.009	0.044	1.003	1.000-1.006
UA		<0.001	1.003	1.002-1.005	<0.001	1.004	1.002-1.006
CEA		0.004	1.001	1.000-1.002	0.122	1.001	1.000-1.002
CA199		0.002	1.001	1.000-1.001	<0.001	1.001	1.000-1.001
BMI		0.472	0.981	0.932-1.033	0.733	1.008	0.961-1.057
Histologic differentiation (poor vs moderate/well)		0.442	1.223	0.732-2.042	0.488	1.187	0.732-1.925
Tumor location	L
	M	0.099	0.597	0.324-1.103	0.28	0.749	0.443-1.266
	U	0.552	0.843	0.481-1.479	0.872	0.958	0.567-1.618
Her2	(Yes vs no)	0.942	0.958	0.303-3.024	0.346	1.485	0.653-3.38
Family history	(Yes vs no)	0.272	0.524	0.165-1.662	0.514	0.742	0.303-1.818
Surgery	(Yes vs no)	0.009	0.6	0.41-0.878	0.041	0.696	0.492-0.985
Chemotherapy	(Yes vs no)	<0.001	0.355	0.242-0.521	0.04	0.643	0.422-0.98
Radiotherapy	(Yes vs no)	0.196	0.663	0.356-1.236	0.107	0.624	0.352-1.107
Target therapy	(Yes vs no)	0.023	0.434	0.212-0.892	0.49	0.828	0.484-1.416
Peritoneal metastasis	(Yes vs no)	0.291	1.251	0.825-1.896	0.496	1.141	0.78-1.669
Liver metastasis	(Yes vs no)	0.839	0.961	0.652-1.415	0.297	0.82	0.565-1.19
Bone metastasis	(Yes vs no)	0.751	0.875	0.385-1.991	0.703	0.862	0.403-1.845
Lung metastasis	(Yes vs no)	0.017	2.076	1.137-3.789	0.436	1.292	0.678-2.465
Ovary metastasis (yes vs no)		0.75	1.133	0.524-2.451	0.65	0.827	0.364-1.879
Distant lymph node metastasis	(Yes vs no)	0.031	1.475	1.037-2.1	0.366	1.162	0.839-1.608
Histologic type (others v adenocarcinoma)		0.372	1.240	0.773-1.990	0.240	1.311	0.835-2.060
T stage	(T4 vs T3)	0.711	0.919	0.590-1.434	0.011	0.616	0.424-0.895
N stage	(N3 vs N2)	0.741	1.078	0.691-1.680	0.706	1.083	0.717-1.635
TNM stage	(IV vs III)	0.004	1.750	1.194-2.565	<0.001	2.222	1.529-3.227

Abbreviations: NLR: neutrophil to lymphocyte ratio; PLR: platelet to lymphocyte ratio; LMR: lymphocyte to monocyte ratio; D-D: D-dimer; FIB: fibrinogen; ALB: albumin; HDL: high-density lipoprotein; GGT: gamma-glutamyltransferase; UA: uric acid; CEA: carcino-embryonic antigen; BMI: body mass index.