Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with βS Haplotype in Children with Sickle Cell Anemia
Table 1
Hematological characteristics of individuals with SCA with or without HU treatment.
Hematological variables
SCA-HU+ , (25th–75th per)
SCA-HU- , (25th–75th per)
value
Red blood cell (×1012/L)
2.69 (2.15–3.18)
2.66 (2.45–3.22)
0.533
Hemoglobin (g/dL)
8.7 (8–10.4)
8.6 (7.9–9.3)
0.337
Hematocrit (%)
24.9 (22.6–30.4)
24.5 (22.2–27.9)
0.522
MCV (fL)
100.9 (89.7–106.7)
92.2 (89.00–94.50)
0.003
MCH (ρg)
34.3 (30.9–37.1)
31.6 (29.7–32.9)
0.002
MCHC (g/dL)
34 (33.5–35.4)
34.1 (33.3–35.6)
0.890
RDW
20.6 (17.3–22.8)
21.1 (18.70–23.3)
0.398
Reticulocytes (%)
7.1 (5.7–8.7)
8.00 (5.4–9.6)
0.728
WBC (×106/L)
9335 (5860–13100)
12300 (10500–14500)
0.014
Neutrophils (×106/L)
4400 (2602–6514)
5280 (4170–6380)
0.250
Eosinophils (×106/L)
306 (96–693)
679 (272–1408)
0.017
Basophils (×106/L)
32 (0–96)
120 (0–158)
0.041
Atypical lymphocytes (×106/L)
0 (0–54)
104 (0–380)
0.014
Typical lymphocytes (×106/L)
3930 (2533–5328)
4921 (3770–6950)
0.033
Monocytes (×106/L)
720 (393–879)
896 (582–1390)
0.041
Platelets (×103/mL)
374 (275–441)
392 (321–463)
0.610
MPV
5.8 (5.2–7)
5.70 (5.20–6.90)
0.856
HbS (%)
80.3 (73.2–86.95)
85.3 (80.1–88.2)
0.286
HbF (%)
9.6 (6.8–15.9)
8.2 (5.7–9.9)
0.072
HbA2 (%)
4.4 (3.9–5.4)
5.55 (4.15–6.90)
0.078
SCA-HU+: individuals with SCA with HU treatment; SCA-HU-: individuals with SCA without HU treatment; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red blood cell distribution width; WBC: white blood cell; MPV: mean platelet volume; HbS: hemoglobin variant S; HbF: fetal hemoglobin; HbA2: normal hemoglobin A2; : number; : median; per: percentile. Mann-Whitney test.
