Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with β^S Haplotype in Children with Sickle Cell Anemia

Table 3

β^S haplotype distribution of individuals with SCA (SCA_total), with HU treatment (SCA-HU⁺) and without HU treatment (SCA-HU^-) according to the median level of CML.

(a) SCA_total

Genotype	CML		Total, (%)
	≤239.33 ng/mL; (%)	>239.33 ng/mL; (%)
Bantu/Bantu	3 (5.8)	8 (15.4)	11 (21.2)	7.909	0.048
Bantu/Benin	5 (9.6)	16 (30.8)	21 (40.4)
Bantu/atypical	2 (3.8)	0 (0.0)	2 (3.8)
Benin/Benin	10 (19.2)	8 (15.4)	18 (34.6)
Total	20 (38.5)	32 (61.5)	52 (100)

CML: N^ε-carboxymethyllysine; : Pearson chi-square. Bantu/Bantu versus Bantu/Benin, Bantu/atypical, and Benin/Benin.

(b) SCA-HU⁺

Genotype	CML		Total, (%)
	≤256.10 ng/mL; (%)	>256.10 ng/mL; (%)
Bantu/Bantu	1 (4.2)	3 (12.5)	4 (16.7)	1.929	0.381
Bantu/Benin	4 (16.7)	5 (20.8)	9 (37.5)
Benin/Benin	7 (29.2)	4 (16.7)	11 (45.8)
Total	12 (50.0)	12 (50.0)	24 (100)

CML: N^ε-carboxymethyllysine; : Pearson chi-square. Bantu/Bantu versus Bantu/Benin, Bantu/atypical, and Benin/Benin.

(c) SCA-HU^-

Genotype	CML		Total, (%)
	≤237.39 ng/mL; (%)	>237.39 ng/mL; (%)
Bantu/Bantu	3 (10.7)	4 (14.3)	7 (25.0)	2.619	0.454
Bantu/Benin	5 (17.9)	7 (25.0)	12 (42.9)
Bantu/atypical	2 (7.1)	0 (0.0)	2 (7.1)
Benin/Benin	4 (14.3)	3 (10.7)	7 (25.0)
Total	14 (50.0)	14 (50.0)	28 (100)

CML: N^ε-carboxymethyllysine; : Pearson chi-square. Bantu/Bantu versus Bantu/Benin, Bantu/atypical, and Benin/Benin.