Prognostic Value of Combined Analysis of CTLA-4 and PLR in Esophageal Squamous Cell Carcinoma (ESCC) Patients

Table 1

Univariate and multivariate Cox regression analyses estimating the risk factors of OS in ESCC patients.

Variable	Univariate analyses			Multivariate analyses
	HR	95% CI	value	HR	95% CI	value
Gender	0.389	0.094-1.612	0.193
Age	0.683	0.268-1.738	0.424
KPS	1.237	0.674-2.271	0.493
Drinking	0.943	0.505-1.760	0.854
Smoking	1.449	0.762-2.756	0.258
Weight loss	1.116	0.579-2.152	0.742
Histological grade	0.832	0.454-1.527	0.553
Location	2.706	0.652-11.237	0.171
Length	1.991	0.949-4.177	0.069
T stage	2.718	1.250-5.913	0.012	3.168	0.320-31.376	0.324
N stage	3.464	1.841-6.517	0.000	5.194	0.547-49.265	0.151
TNM stage	2.218	1.428-3.171	0.000	0.537	0.064-4.508	0.567
Resection margin	0.935	0.226-3.875	0.926
Adjuvant radiotherapy	2.107	1.116-3.978	0.022	2.104	1.109-3.993	0.023
Adjuvant chemotherapy	1.829	0.941-3.556	0.075
T-CTLA-4(-) +PLR (-)	2.031	1.083-3.807	0.027	2.025	1.071-3.826	0.030

Abbreviations: OS: overall survival; ESCC: esophageal squamous cell carcinoma; HR: hazard ratio; CI: confidence interval; KPS: Karnofsky; T-CTLA-4: tumor cell cytotoxic T-lymphocyte-associated antigen-4; PLR: platelet lymphocyte ratio.