Circulating Levels of miR-574-5p Are Associated with Neurological Outcome after Cardiac Arrest in Women: A Target Temperature Management (TTM) Trial Substudy

Table 2

Added value of miR-574-5p to predict neurological outcome in all patients and in men and women separately.

Models	AIC	value	IDI [95% CI]	value
All patients ()
Baseline model	493.7
Baseline model + miR-574-5p	494.9	0.376 (vs. baseline)	0.0009 [-0.0016; 0.0035]	0.465
Men ()
Baseline model	395.2
Baseline model + miR-574-5p	397.1	0.842 (vs. baseline)	0.0002 [-0.0005; 0.0009]	0.644
Women ()
Baseline model	109.3
Baseline model + miR-574-5p	105.7	0.018 (vs. baseline)	0.0433 [0.0071; 0.0794]	0.019

The baseline model includes age, sex, bystander cardiopulmonary resuscitation (CPR), first monitored rhythm, time from cardiac arrest to ROSC, initial serum lactate levels, shock on admission, NSE levels at 48 h, and targeted temperature regimen. Log10-transformed miR-574-5 values were used in these analyses. AIC: Akaike information criteria. A lower AIC indicates a better predictive value. IDI: integrated discrimination improvement. A higher IDI indicates a better predictive value. The statistical significance was assessed using the likelihood ratio test. A value < 0.05 was considered significant and is highlighted in bold.