Inflammation-Related Patterns in the Clinical Staging and Severity Assessment of Chronic Kidney Disease

Figure 7

Functional interaction between different molecules involved in inflammation and MBDs in CKD. The coloured nodes are represented by query proteins and the first shell of interactors. Edges represent protein-protein functional associations, assigned with different colour codes, as follows: a blue edge indicates known interactions from curated databases, a pink edge indicates known interactions that have been experimentally determined, a green edge indicates predicted interactions in the gene neighbourhood, a red edge indicates predicted interactions for gene fusions, a blue-ink edge indicates predicted interactions for gene cooccurrences, a light-green edge indicates other interactions derived from text mining, and a black edge indicates gene coexpression derived from other databases. Abbreviations: CYP24A1: calcitriol, 1,25-dihydroxyvitamin D₃, and 1,25OH₂D₃; SPP1: osteopontin, OPN; TNFRSF11B: osteoprotegerin, OPG; BGLAP: osteocalcin, OC; CXCL8: IL-8, interleukin-8; GC: vitamin D binding protein, DBP; VDR: vitamin D receptor.