Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis
Table 1
Clinical and biochemical characteristics of the study subjects.
Healthy control
lgAVN
lgAV without nephritis
Subjects,
76
43
66
Demographics
Age
>0.05
Gender (male/female)
44/32
26/17
37/29
>0.05
Lipid profiles
TG (mmol/L)
2.75 (1.12-3.39)b
1.26 (0.8-1.66)a
1.08 (0.67-1.87)a
<0.05
TC (mmol/L)
0.84 (0.59-2.99)b
3.93 (3.44-4.56)a
3.98 (3.19-4.85)a
<0.05
HDL-C (mmol/L)
1.23 (1.05-1.37)
1.21 (1-1.36)
1.29 (1.03-1.55)
>0.05
LDL-C (mmol/L)
1.9 (1.5-2.16)b
2.21 (1.77-2.75)a
2.1 (1.57-2.78)a
<0.05
apoA (g/L)
1.06 (0.99-1.15)b
0.9 (0.75-1.04)a
0.93 (0.78-1.06)a
<0.05
apoB (g/L)
0.57 (0.47-0.66)
0.58 (0.49-0.7)
0.58 (0.45-0.72)
>0.05
apoM (mg/L)
18.17 (15.83-20.22)a
23.92 (21.25-26.1)b
25.96 (23.50-27.46)c
<0.05
Kidney biochemical profiles
BUN (μmol/L)
3.8 (3.25-4.47)
4.02 (2.86-5.5)
4.09 (2.99-4.95)
>0.05
CRE (μmol/L)
30.9 (24.23-36.4)a
41.1 (36-53)b
35.55 (30.75-42.43)c
<0.05
UA (g/L)
230.05 (181.93-269.63)a
265 (218.6-330.3)b
223.3 (187.13-281.55)a
<0.05
hs-CRP (mg/L)
/
1.94 (1.02-3.87)
3.74 (1.37-12.1)
<0.05
Immunoglobulins
lgG (g/L)
/
8.4 (6.16-11)
9.97 (8.29-11.7)
<0.05
lgM (g/L)
/
2 (154-2.35)
2.2 (1.52-3.19)
>0.05
lgA (g/L)
/
1.25 (0.84-1.42)
1.05 (0.87-1.56)
>0.05
lgE (g/L)
/
150.8 (59.09-447.3)
275.05 (119.38-298.63)
>0.05
Complements
C3 (g/L)
/
0.95 (0.8-1.13)
1 (0.9-1.15)
>0.05
C4 (g/L)
/
0.18 (0.15-0.23)
0.23 (0.18-0.28)
<0.05
abc means not sharing a common superscript are significantly different among the healthy controls, lgAVN, and lgAV without nephritis groups at . Data are presented as median (range). TG: triglyceride; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; apoA1: apolipoprotein A1; apoB: apolipoprotein B; apoM: apolipoprotein M.
