Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis

Figure 2

The levels of peripheral blood hsa_circ_0002715, hsa_circ_0000367, hsa_circ_0001947, and hsa_circ_0035197 in new-onset RA patients. The levels of peripheral blood hsa_circ_0002715 (a, e), hsa_circ_0000367 (b, f), hsa_circ_0001947(c, g), and hsa_circ_0035197 (d, h) were significantly higher in new-onset RA patients than in HC and AS patients. The levels of peripheral blood hsa_circ_0002715 (e) were significantly lower in new-onset RA patients than in SLE patients, while the levels of peripheral blood hsa_circ_0000367 (f), hsa_circ_0000367 (g), and hsa_circ_0035197 (h) were significantly higher in new-onset RA patients than in SLE patients. The levels of peripheral blood hsa_circ_0001947 (g) and hsa_circ_0035197 (h) were significantly higher in new-onset RA patients than in UA patients, while the levels of peripheral blood hsa_circ_0002715 (e) and hsa_circ_0000367 (f) showed no significant difference in the peripheral blood of new-onset RA patients and UA. Ankylosing spondylitis (AS), healthy controls (HC), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and undiagnosed arthritis (UA).

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