PTPN22 Gene Polymorphisms Are Associated with Susceptibility to Large Artery Atherosclerotic Stroke and Microembolic Signals
Table 4
Genotypes and allelic frequencies of PTPN22 SNPs in MES (+) and MES (−) groups.
SNP site
MES (+) (%)
MES (-) (%)
Univariate analysis OR (95% CI)a
value
Multivariate analysis adjusted OR (95% CI)b
value
rs2476599
Genotype
GG
84 (88.4%)
239 (88.8%)
1.000 (reference)
-
1.000 (reference)
-
GA
10 (10.5%)
28 (10.4%)
1.016 (0.473-2.181)
0.967
0.914 (0.418-2.000)
0.823
AA
1 (1.1%)
2 (0.7%)
1.423 (0.127-15.892)
1.000
1.249 (0.109-14.291)
0.858
GA+AA
11 (11.6%)
30 (11.2%)
1.043 (0.501-2.174)
0.910
0.938 (0.442-1.990)
0.867
Allele
G
178 (93.7%)
506 (94.1%)
1.000 (reference)
-
1.000 (reference)
-
A
12 (6.3%)
32 (5.9%)
1.066 (0.537-2.115)
0.855
0.963 (0.480-1.934)
0.916
rs1217414
Genotype
CC
77 (81.1%)
225 (83.6%)
1.000 (reference)
-
1.000 (reference)
-
CT
17 (17.9%)
40 (14.9%)
1.242 (0.666-2.317)
0.495
1.161 (0.613-2.200)
0.647
TT
1 (1.1%)
4 (1.5%)
0.731 (0.080-6.636)
1.000
0.726 (0.078-6.715)
0.778
CT+TT
18 (18.9%)
44 (16.4%)
1.195 (0.652-2.192)
0.564
1.123 (0.603-2.093)
0.715
Allele
C
171 (90.0%)
490 (91.1%)
1.000 (reference)
-
1.000 (reference)
-
T
19 (10.0%)
48 (8.9%)
1.134 (0.649-1.984)
0.659
1.074 (0.608-1.898)
0.806
rs2488457
Genotype
CC
25 (26.3%)
100 (37.2%)
1.000 (reference)
-
1.000 (reference)
-
CG
42 (44.2%)
125 (46.5%)
1.344 (0.767-2.354)
0.300
1.465 (0.822-2.611)
0.195
GG
28 (29.5%)
44 (16.4%)
2.545 (1.335-4.854)
0.004
2.591 (1.339-5.011)
0.005
CG+GG
70 (73.7%)
169 (62.8%)
1.657 (0.986-2.785)
0.055
1.780 (1.042-3.039)
0.035
Allele
C
92 (48.4%)
325 (60.4%)
1.000 (reference)
-
1.000 (reference)
-
G
98 (51.6%)
213 (39.6%)
1.625 (1.165-2.267)
0.004
1.652 (1.177-2.319)
0.004
aUnivariate analysis; bmultivariate analysis (covariates: sex, age, history of smoking and drinking, hypertension, diabetes, dyslipidemia, and family history of ischemic stroke events).
