PTPN22 Gene Polymorphisms Are Associated with Susceptibility to Large Artery Atherosclerotic Stroke and Microembolic Signals

Table 7

Interaction analysis of rs2488457 with drinking or smoking by using logistic regression.

SNP site	Smoking			Drinking
rs2488457		Adjusted OR (95% CI)^a	value		Adjusted OR (95% CI)^b	value
CC	No	1.000 (reference)	-	No	1.000 (reference)	-
CC	Yes	1.778 (0.972-3.251)	0.062	Yes	1.278 (0.600-2.721)	0.524
CG+GG	No	1.464 (0.987-2.172)	0.058	No	1.389 (0.944-2.045)	0.096
CG+GG	Yes	2.492 (1.510-4.114)	<0.001	Yes	2.019 (0.997-4.090)	0.051

^aAdjusted for sex, age, history of drinking, diabetes, hypertension, dyslipidemia, and family history of ischemic stroke events; ^badjusted for sex, age, history of smoking, hypertension, diabetes, dyslipidemia, and family history of ischemic stroke events.