Research Article

Prognostic Significance of CIP2A in Esophagogastric Junction Adenocarcinoma: A Study of 65 Patients and a Meta-Analysis

Table 3

Studies and data included in this meta-analysis.

AuthorYearPatients’ country of originCancer typeNo. of patientsStage/gradeDetection methodPercentage of CIP2A high expression, cutoff valueMedian follow- up monthsOutcomeSurvival analysis method

Böckelman2011FinlandTongue cancer71Grade I-IIIIHC32/71 (45.1%), 94.8OSM
Böckelman2011FinlandSerous ovarian cancer524I-IVIHC212/524 (40.5%), 105.6DSSM
Dong2011ChinaNon-small-cell lung cancer90I-IVIHC65/90 (72.2%), NAOSM
Ren2011ChinaRenal cell carcinoma85I-IVIHC36/85 (42.4%), staining intensity: 2-3NAOSM
He2012ChinaHepatocellular carcinoma136I-IVIHC85/136 (62.5%), 2+ to 3+NAOS, DFSM
Huang2012ChinaHepatocellular carcinoma136I-IIIRT-PCR68/136 (50.0%), above median mRNA expression levels39OS, RFSM
Sung2013China (Taiwan)Lung adenocarcinoma98I-IIIRT-PCR49/98 (50.0%), median value of mRNA expression levels in lung tumors21.5OSM
Wiegering2013GermanyColon cancer104I-IVRT-PCRNA, above median mRNA expression levelsNAOSM
Xue2013ChinaBladder urothelial cell carcinoma117Ta, T1-T4IHC85/117 (72.6%), + to +++57.1OSM
Yu2013ChinaBreast cancer164Grade I-IIIIHC58/164 (35.4%), 1+ or 2+NADSSM
Liu2014ChinaNasopharyngeal carcinoma280I-IVIHC184/280 (65.7%), ROC curves63.6OS, DFSM
Chen2015China (Taiwan)Colorectal cancer220I-IVIHC91/220 (41.4%), NAOSM
Tang2015ChinaClear cell renal cell carcinoma131T1-T4IHC88/131 (67.2%), NAOS, DFSM
Wang2017ChinaCervical cancer127I-IVIHCNA, + to +++NAOS, DFSU
Xu2017ChinaGallbladder carcinoma65I-IVIHC42/65 (64.6%), moderate or strong, 5-100% positive cellsNAOSM

IHC: immunohistochemistry; NA: not available; OS: overall survival; DSS: disease-specific survival; DFS: disease-free survival; RFS: recurrence-free survival; M: multivariate Cox proportional hazard regression; U: univariate survival analysis.