Decreased Expression of Urinary Mammalian Target of Rapamycin mRNA Is Related to Chronic Renal Fibrosis in IgAN

Table 2

Clinical and pathological parameters of patients with IgAN with different renal fibrosis degrees.

	None-mild fibrosis ()	Moderate fibrosis ()	Severe fibrosis ()	value
Age (years)	^a	^a	^a	0.254^c
Gender (male/female)	30/34	33/21	19/17	0.526^d
Proteinuria (g/day)	^a	^a	^a	0.125^c
Scr (μmol/l)	^a	^a	^a	0.021^c
BUN (mmol/l)	^a	^a	^a	0.074^c
Cystatin C (mg/l)	^a	^a	^a	0.042^c
eGFR (ml/min per 1.73 m^2)	^a	^a	^a	<0.001^c
SBP (mmHg)	^a	^a	^a	<0.001^c
DBP (mmHg)	^a	^a	^a	0.018^c
Usage of ACEI/ARB	51	32	13	0.067^d
Usage of diuretic	38	35	10	0.053^d
Relative mTOR mRNA expression	0.427 (0.382-0.597)^b	0.312 (0.276-0.341)^b	0.223 (0.158-0.289)^b	0.024^e
Score of glomerular sclerosis	0.5 (0-0.8)^b	1.8 (0.5-3.0)^b	2.5 (2.0-4.8)^b	<0.001^e
Score of TIF (%)	5 (0-4)^b	30 (27-51)^b	61 (52-90)^b	<0.001^e

^aData are presented as means (±SD). ^bData are presented as the median (min, max). ^cStudent’s -test. ^d tests. ^eMann–Whitney test. Abbreviations: Scr: serum creatinine; eGFR: estimated glomerular filtration rate; SBP: systolic blood pressure; DBP: diastolic blood pressure; TIF: tubulointerstitial fibrosis.