circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer

Table 2

Univariate and multivariable analyses of overall survival and disease-free survival after surgery.

Variables	Overall survival					Disease-free survival
	Univariate		Multivariate			Univariate		Multivariate
	Log-rank		HR	95% CI		Log-rank		HR	95% CI
Age (≥60 years vs. <60 years)	0.008	0.930	1.307	0.447-3.821	0.624	0.019	0.892	1.546	0.624-3.834	0.347
Gender (male vs. female)	0.068	0.794	0.460	0.162-1.307	0.145	0.058	0.809	0.763	0.314-1.851	0.549
Tumor location (upper/middle vs. down)	0.011	0.915	2.294	0.958-5.489	0.062	0.769	0.381	0.759	0.302-1.912	0.559
Tumor size (≥5 cm vs. <5 cm)	2.140	0.144	1.457	0.517-4.107	0.477	2.415	0.120	2.015	0.918-4.423	0.081
Differentiation (poor vs. well/moderate)	3.658	0.056	1.951	0.807-4.718	0.138	4.953	0.026	3.514	1.349-9.153	0.010
Lymph node metastasis (positive vs. negative)	6.420	0.011	4.296	1.420-12.993	0.010	7.387	0.007	1.794	0.818-3.930	0.144
Vascular invasion (yes vs. no)	5.826	0.016	1.986	0.806-4.893	0.136	4.713	0.030	1.393	0.613-3.165	0.428
AJCC stage (III vs. I/II)	12.441	< 0.001	5.465	1.501-19.892	0.010	9.254	0.002	3.175	1.261-7.995	0.014
circSMARCA5 expression (high vs. low)	7.264	0.007	0.383	0.154-0.954	0.039	9.440	0.002	0.347	0.146-0.823	0.016

indicates statistical significance. HR: hazard ratio; CI: confidence interval; AJCC: American Joint Committee on Cancer.