Review Article
Prognostic Value of MicroRNA-497 in Various Cancers: A Systematic Review and Meta-Analysis
Table 1
Characteristics of studies included in the meta-analysis.
| | Author | Year | Country | Ethnicity | Number | Cancer type | Stage | Sample | Method | Follow-up (months) | Cut-off | Survival analysis | Hazard ratio | NOS | | OS | DFS/RFS |
| | Zhang et al. [15] | 2016 | China | Asian | 86 | 86 | HCC | I-IV (TNM) | Frozen tissue | qRT-PCR | 60 | Median | OS/DFS | HR/SC | 8 | | Luo et al. [13] | 2013 | China | Asian | 60 | 60 | Cervical cancer | I-II (FIGO) | Frozen tissue | qRT-PCR | 60 | Mean (0.44) | OS/DFS | HR/SC | 8 | | Creevey et al. [12] | 2013 | Ireland | Caucasian | 143 | 143 | Neuroblastoma | 1-4 s (INSS) | Frozen tissue | qRT-PCR | 60 | First Quartile | OS | SC | 6 | | Wang et al. [33] | 2014 | China | Asian | 96 | 96 | Ovarian cancer | I-IV (TNM) | Frozen tissue | qRT-PCR | 60 | NR | OS/RFS | SC | 8 | | Xu et al. [34] | 2014 | China | Asian | 87 | / | Pancreatic cancer | I-IV (TNM) | Frozen tissue | qRT-PCR | 87 | Score | OS | HR/SC | 8 | | Liu et al. [18] | 2016 | China | Asian | 240 | / | Breast cancer | I-III (TNM) | Frozen tissue | qRT-PCR | 80 | Median (1.60) | OS | HR/SC | 7 | | Feng et al. [35] | 2016 | China | Asian | 110 | / | Gliomas | I-IV (TNM) | Frozen tissue | qRT-PCR | 60 | Median (1.73) | OS | HR/SC | 7 | | Huang et al. [36] | 2015 | China | Asian | 51 | / | NSCLC | I-III (TNM) | Frozen tissue | qRT-PCR | 60 | Median | OS | SC | 8 | | Zhao et al. [17] | 2015 | China | Asian | 86 | / | Renal cancer | T1-T4 (TNM) | Frozen tissue | qRT-PCR | 60 | Mean | OS | HR/SC | 7 | | Li et al. [14] | 2014 | China | Asian | 97 | / | GC | I-IV (TNM) | Frozen tissue | qRT-PCR | 60 | Median | OS | SC | 6 | | Troppan et al. [37] | 2015 | Austria | Caucasian | 58 | 58 | DLBCL | I-IV (TNM) | Frozen tissue | qRT-PCR | 120 | Median | OS/DFS | HR/SC | 6 | | Song et al. [19] | 2017 | China | Asian | 46 | / | Osteosarcoma | I-III (TNM) | Frozen tissue | qRT-PCR | 72 | Mean | OS | SC | 7 | | Wang et al. [38] | 2012 | China | Asian | 57 | / | Colorectal cancer | I-IV (TNM) | Frozen tissue | qRT-PCR | 60 | N/T = 2 | OS | SC | 7 | | Zhang [20] | 2016 | China | Asian | 39 | / | Ewing sarcoma | NR | Frozen tissue | qRT-PCR | 90 | NR | OS | SC | 6 | | Xie and Wang [16] | 2017 | China | Asian | 61 | / | HCC | I-IV (TNM) | Frozen tissue | qRT-PCR | 60 | Median (0.24) | OS | HR/SC | 8 |
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OS: overall survival; DFS: disease-free survival; RFS: relapse-free survival; HCC: hepatocellular carcinoma; NSCLC: non-small-cell lung cancer; GC: gastric cancer; DLBCL: diffuse large B-cell lymphoma; TNM: tumor node metastasis; FIGO: International Federation of Gynaecology and Obstetrics staging criteria; INSS: International neuroblastoma staging system; NR: not reported; qRT-PCR: quantitative real-time PCR; HR: hazard ratio; SC: survival curve; NOS: Newcastle-Ottawa Scale. Written in Chinese. |
