Response to: Comment on “Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients”

Table 2

Test of substitution saturation by Xia’s method implemented in DAMBE [9, 10] on NS5A and NS5B datasets used for genotyping purposes.

	sequences	Iss	Symmetrical topology		Asymmetrical topology
			Iss.cSym		Iss.cAsym
NS5A	4	0.434	0.819	0.0000	0.787	0.0000
	8	0.427	0.787	0.0000	0.681	0.0000
	16	0.433	0.77	0.0000	0.571	0.0000
	32	0.448	0.746	0.0000	0.439	0.7354
NS5B	4	0.354	0.785	0.0000	0.756	0.0000
	8	0.361	0.739	0.0000	0.628	0.0000
	16	0.359	0.694	0.0000	0.485	0.0000
	32	0.365	0.687	0.0000	0.358	0.8151

I_ss: index of substitution saturation; I_ss.c: critical index of substitution saturation; : value for two-tailed tests.