Optimizing the Use of the Gamma-Glutamyl Transpeptidase-to-Platelet Ratio and Transient Elastography to Identify Liver Cirrhosis in Patients with Chronic Hepatitis B Concurrent with Nonalcoholic Fatty Liver Disease

Table 4

Performance of GPR alone, TE alone, both tests for all patients, and the 2-step approach in the assessment of cirrhosis.

Variables	GPR alone	TE alone	Both tests for all patients	2-step approach	value (both tests vs. 2-step approach)
Sensitivity, % ()	91.7 (11/12)	94.1 (16/17)	93.8 (15/16)	88.2 (15/17)	0.963
Specificity, % ()	85.2 (46/54)	91.0 (101/111)	91.3 (95/104)	91.5 (97/106)	0.846
PPV, % ()	57.9 (11/19)	61.5 (16/26)	62.5 (15/24)	62.5 (15/24)	1.000
NPV, % ()	97.9 (46/47)	99.0 (101/102)	99.0 (95/96)	98.0 (97/99)	0.988
Positive LR	6.19	10.45	10.83	10.39	—
Negative LR	0.10	0.06	0.07	0.13	—
Misclassification, % ()	13.6 (9/66)	8.6 (11/128)	8.3 (10/120)	8.9 (11/123)	0.866
Indeterminate, % ()	54.5 (79/145)	11.7 (17/145)	17.2 (25/145)	15.2 (22/145)	0.750
Accuracy, % ()	86.4 (57/66)	91.4 (117/128)	91.7 (110/120)	91.1 (112/123)	0.866

TE: transient elastography; GPR: gamma-glutamyl transpeptidase-to-platelet ratio; PPV: positive predictive value; NPV: negative predictive value; LR: likelihood ratio.