Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance

Table 1

The predicted miRNAs targeting hsa_circ_0005556 and their potential functions in tumors.

MicroRNA	Target	Tumor type	Function	Ref.
miR-548c-3p	HIF-1α, VEGF	Breast cancer	Proliferation, invasion, chemotherapy resistance	[16, 17]
	c-Myb	Glioma	Proliferation, migration	[18]
	ITGAV	Osteosarcoma	Proliferation	[19]
	——	Gastric cancer	Differential expression in HP(+) and HP(-)	[20]
miR-587	PPP2R1B	Colorectal cancer	Chemotherapy resistance	[21]
	——	Glioblastoma multiforme	Prognosis	[22]
miR-4739	β-Catenin	Gastric cancer	Proliferation, invasion, chemosensitivity	[23]
miR-125a-3p	TIM-3	Acute myeloid leukemia	——	[24]
miR-125a-3p	Fyn	Pancreatic ductal adenocarcinoma	Chemosensitivity	[25]
	MTA1	Lung cancer	Proliferation, migration, invasion	[26]
	CDK3	Lung cancer	——	[27]
miR-297	VEGFA	Oral squamous cell carcinoma	Proliferation	[28]

HIF-1α: hypoxia-inducible factor-1 alpha, VEGF: vascular endothelial growth factor, c-Myb: protooncogene c-Myb, ITGAV: integrin αv, TIM-3: T cell immunoglobulin and mucin-3, MTA1: metastasis-associated gene 1, CDK3: cyclin-dependent kinase 3, VEGFA: vascular endothelial growth factor A.