An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease
Table 3
Genotype distributions of the AGT gene polymorphism and coronary artery aneurysm among Kawasaki disease patients.
Genotype/allele
CAA ()
NCAA ()
a
Crude OR (95% CI)
Adjusted OR (95% CI)b
b
rs699(A>G)
AA
1 (0.96)
14 (2.13)
1.00
1.00
AG
23 (22.12)
177 (26.98)
1.82 (0.23-14.48)
0.572
2.00 (0.25-16.88)
0.515
GG
80 (76.92)
465 (70.88)
2.41 (0.31-18.57)
0.399
2.85 (0.37-20.98)
0.344
Additive
0.365
1.37 (0.87-2.14)
0.174
1.40 (0.89-2.20)
0.142
Dominant
103 (99.04)
642 (97.87)
0.382
2.25 (0.29-17.26)
0.437
2.50 (0.32-19.40)
0.381
Recessive
24 (23.08)
191 (29.12)
0.196
1.37 (0.84-2.23)
0.206
1.40 (0.86-2.29)
0.175
A
25 (12.02)
205 (15.62)
0.178
G
183 (87.98)
1107 (84.38)
rs5050(T>G)
TT
64 (61.54)
471 (71.80)
1.00
1.00
TG
35 (33.65)
170 (25.91)
1.15 (0.96-2.37)
0.069
1.48 (0.94-2.32)
0.089
GG
5 (4.81)
15 (2.29)
2.45 (0.86-6.98)
0.092
2.58 (0.90-7.39)
0.077
Additive
0.079
1.53 (1.07-2.21)
0.021
1.53 (1.06-2.21)
0.024
Dominant
40 (38.46)
185 (28.20)
0.037
1.59 (1.04-2.45)
0.034
1.56 (1.01-2.41)
0.043
Recessive
99 (95.19)
641 (97.71)
0.172
2.16 (0.77-6.07)
0.147
2.30 (0.81-6.50)
0.117
T
163 (73.37)
1112 (84.76)
0.020
G
45 (21.63)
200 (15.24)
CAA: coronary artery aneurysm; NCAA: no coronary artery aneurysm. a test of the genotype distributions between coronary artery aneurysm and no coronary artery aneurysm among patients with Kawasaki disease. bAdjusted for age and sex.
