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Research Article

An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease

Table 3

Genotype distributions of the AGT gene polymorphism and coronary artery aneurysm among Kawasaki disease patients.

Genotype/alleleCAA ()NCAA ()aCrude OR (95% CI)Adjusted OR (95% CI)bb

rs699(A>G)
 AA1 (0.96)14 (2.13)1.001.00
 AG23 (22.12)177 (26.98)1.82 (0.23-14.48)0.5722.00 (0.25-16.88)0.515
 GG80 (76.92)465 (70.88)2.41 (0.31-18.57)0.3992.85 (0.37-20.98)0.344
 Additive0.3651.37 (0.87-2.14)0.1741.40 (0.89-2.20)0.142
 Dominant103 (99.04)642 (97.87)0.3822.25 (0.29-17.26)0.4372.50 (0.32-19.40)0.381
 Recessive24 (23.08)191 (29.12)0.1961.37 (0.84-2.23)0.2061.40 (0.86-2.29)0.175
 A25 (12.02)205 (15.62)0.178
 G183 (87.98)1107 (84.38)
rs5050(T>G)
 TT64 (61.54)471 (71.80)1.001.00
 TG35 (33.65)170 (25.91)1.15 (0.96-2.37)0.0691.48 (0.94-2.32)0.089
 GG5 (4.81)15 (2.29)2.45 (0.86-6.98)0.0922.58 (0.90-7.39)0.077
 Additive0.0791.53 (1.07-2.21)0.0211.53 (1.06-2.21)0.024
 Dominant40 (38.46)185 (28.20)0.0371.59 (1.04-2.45)0.0341.56 (1.01-2.41)0.043
 Recessive99 (95.19)641 (97.71)0.1722.16 (0.77-6.07)0.1472.30 (0.81-6.50)0.117
 T163 (73.37)1112 (84.76)0.020
 G45 (21.63)200 (15.24)

CAA: coronary artery aneurysm; NCAA: no coronary artery aneurysm. a test of the genotype distributions between coronary artery aneurysm and no coronary artery aneurysm among patients with Kawasaki disease. bAdjusted for age and sex.

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