Prognostic Value of MicroRNAs in Patients after Myocardial Infarction: A Substudy of PRAGUE-18

Table 2

Relationship between individual marker levels and one-year mortality.

Marker	Gene	Concentration	Patients, number (%)	Survivors, number (%)	Nonsurvivors, number (%)	value
	Locus (OMIM)
MicroRNAs (relative concentration)
miR-133a	MIR133A1/MIR133A2	<0.330	93 (76.2)	91 (78.4)	2 (33.3)	0.028
	18q11.2/20q13.33	≥0.330	29 (23.8)	25 (21.6)	4 (66.7)
miR-1	MIR1-1/MIR1-2	<0.031	78 (63.9)	76 (65.5)	2 (33.3)	0.187
	20q13.33/18q11.2	≥0.031	44 (36.1)	40 (34.5)	4 (66.7)
miR-499	MIR499	<0.088	63 (51.6)	63 (54.3)	0 (0.0)	0.011
	20q11.22	≥0.088	59 (48.4)	53 (45.7)	6 (100.0)
Standard biomarkers (concentration in ng/L)
hsTnT	TNN2	<154.5	77 (63.6)	75 (65.2)	2 (33.3)	0.189
	1q32.1	≥154.5	44 (36.4)	40 (34.8)	4 (66.7)
NT-proBNP	NPPB	<891.5	66 (54.1)	66 (56.9)	0 (0.0)	0.008
	1p36.22	≥891.5	56 (45.9)	50 (43.1)	6 (100.0)

Fisher exact test. NT-proBNP = N-terminal prohormone of brain natriuretic peptide; hsTnT = high-sensitivity troponin.