Research Article
Prognostic Value of MicroRNAs in Patients after Myocardial Infarction: A Substudy of PRAGUE-18
Table 3
Relationship between various combinations of marker levels and one-year mortality.
| | Markers and their levels | Patients, number (%) | Survivors, number (%) | Nonsurvivors, number (%) | value |
| | MicroRNAs | | | | | | miR-133a+miR-1 | | | | | | Both low | 75 (61.5) | 73 (62.9) | 2 (33.3) | 0.045 | | One low and one high | 21 (17.2) | 21 (18.1) | 0 (0.0) | | Both high | 26 (21.3) | 22 (19.0) | 4 (66.7) | | miR-133a+miR-499 | | | | | | Both low | 57 (46.7) | 57 (49.1) | 0 (0.0) | 0.004 | | One low and one high | 42 (34.4) | 40 (34.5) | 2 (33.3) | | Both high | 23 (18.9) | 19 (16.4) | 4 (66.7) | | miR-1+miR-499 | | | | | | Both low | 47 (38.5) | 47 (40.5) | 0 (0.0) | 0.019 | | One low and one high | 47 (38.5) | 45 (38.8) | 2 (33.3) | | Both high | 28 (23.0) | 24 (20.7) | 4 (66.7) | | miR-133a+miR-1+miR-499 | | | | | | All low | 47 (38.5) | 47 (40.5) | 0 (0.0) | 0.003 | | Minimum one low, minimum one high | 55 (45.1) | 53 (45.7) | 2 (33.3) | | All high | 20 (16.4) | 16 (13.8) | 4 (66.7) |
| | Standard biomarkers | | | | | | hsTnT+NT-proBNP | | | | | | Both low | 42 (34.7) | 42 (36.5) | 0 (0.0) | 0.006 | | One low and one high | 58 (47.9) | 56 (48.7) | 2 (33.3) | | Both high | 21 (17.4) | 17 (14.8) | 4 (66.7) |
| | MicroRNAs and standard biomarkers | | | | | | hsTnT+miR-133a | | | | | | Both low | 63 (52.1) | 62 (53.9) | 1 (16.7) | 0.024 | | One low and one high | 43 (35.5) | 41 (35.7) | 2 (33.3) | | Both high | 15 (12.4) | 12 (10.4) | 3 (50.0) | | hsTnT+miR-1 | | | | | | Both low | 53 (43.8) | 52 (45.2) | 1 (16.7) | 0.094 | | One low and one high | 48 (39.7) | 46 (40.0) | 2 (33.3) | | Both high | 20 (16.5) | 17 (14.8) | 3 (50.0) | | hsTnT+miR-499 | | | | | | Both low | 39 (32.2) | 39 (33.9) | 0 (0.0) | 0.005 | | One low and one high | 61 (50.4) | 59 (51.3) | 2 (33.3) | | Both high | 21 (17.4) | 17 (14.8) | 4 (66.7) | | NT-proBNP+miR-133a | | | | | | Both low | 59 (48.4) | 59 (50.9) | 0 (0.0) | 0.003 | | One low and one high | 41 (33.6) | 39 (33.6) | 2 (33.3) | | Both high | 22 (18.0) | 18 (15.5) | 4 (66.7) | | NT-proBNP+miR-1 | | | | | | Both low | 51 (41.8) | 51 (44.0) | 0 (0.0) | 0.014 | | One low and one high | 42 (34.4) | 40 (34.5) | 2 (33.3) | | Both high | 29 (23.8) | 25 (21.6) | 4 (66.7) | | NT-proBNP+miR-499 | | | | | | Both low | 46 (37.7) | 46 (39.7) | 0 (0.0) | 0.001 | | One low and one high | 37 (30.3) | 37 (31.9) | 0 (0.0) | | Both high | 39 (32.0) | 33 (28.4) | 6 (100.0) |
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Fisher exact test: difference between both subgroups. hsTnT = high-sensitivity troponin T; NT-proBNP = N-terminal prohormone of brain natriuretic peptide. |
