Disease Markers / 2019 / Article / Tab 3

Research Article

Prognostic Value of MicroRNAs in Patients after Myocardial Infarction: A Substudy of PRAGUE-18

Table 3

Relationship between various combinations of marker levels and one-year mortality.

Markers and their levelsPatients, number (%)Survivors, number (%)Nonsurvivors, number (%) value

MicroRNAs
miR-133a+miR-1
 Both low75 (61.5)73 (62.9)2 (33.3)0.045
 One low and one high21 (17.2)21 (18.1)0 (0.0)
 Both high26 (21.3)22 (19.0)4 (66.7)
miR-133a+miR-499
 Both low57 (46.7)57 (49.1)0 (0.0)0.004
 One low and one high42 (34.4)40 (34.5)2 (33.3)
 Both high23 (18.9)19 (16.4)4 (66.7)
miR-1+miR-499
 Both low47 (38.5)47 (40.5)0 (0.0)0.019
 One low and one high47 (38.5)45 (38.8)2 (33.3)
 Both high28 (23.0)24 (20.7)4 (66.7)
miR-133a+miR-1+miR-499
 All low47 (38.5)47 (40.5)0 (0.0)0.003
 Minimum one low, minimum one high55 (45.1)53 (45.7)2 (33.3)
 All high20 (16.4)16 (13.8)4 (66.7)

Standard biomarkers
hsTnT+NT-proBNP
 Both low42 (34.7)42 (36.5)0 (0.0)0.006
 One low and one high58 (47.9)56 (48.7)2 (33.3)
 Both high21 (17.4)17 (14.8)4 (66.7)

MicroRNAs and standard biomarkers
hsTnT+miR-133a
 Both low63 (52.1)62 (53.9)1 (16.7)0.024
 One low and one high43 (35.5)41 (35.7)2 (33.3)
 Both high15 (12.4)12 (10.4)3 (50.0)
hsTnT+miR-1
 Both low53 (43.8)52 (45.2)1 (16.7)0.094
 One low and one high48 (39.7)46 (40.0)2 (33.3)
 Both high20 (16.5)17 (14.8)3 (50.0)
hsTnT+miR-499
 Both low39 (32.2)39 (33.9)0 (0.0)0.005
 One low and one high61 (50.4)59 (51.3)2 (33.3)
 Both high21 (17.4)17 (14.8)4 (66.7)
NT-proBNP+miR-133a
 Both low59 (48.4)59 (50.9)0 (0.0)0.003
 One low and one high41 (33.6)39 (33.6)2 (33.3)
 Both high22 (18.0)18 (15.5)4 (66.7)
NT-proBNP+miR-1
 Both low51 (41.8)51 (44.0)0 (0.0)0.014
 One low and one high42 (34.4)40 (34.5)2 (33.3)
 Both high29 (23.8)25 (21.6)4 (66.7)
NT-proBNP+miR-499
 Both low46 (37.7)46 (39.7)0 (0.0)0.001
 One low and one high37 (30.3)37 (31.9)0 (0.0)
 Both high39 (32.0)33 (28.4)6 (100.0)

Fisher exact test: difference between both subgroups. hsTnT = high-sensitivity troponin T; NT-proBNP = N-terminal prohormone of brain natriuretic peptide.

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