Systematic Meta-analysis Revealed an Association of PGC-1α rs8192678 Polymorphism in Type 2 Diabetes Mellitus
Table 3
Summary of meta-analysis of association between PGC-1αrs8192678 polymorphism and T2DM.
Genetic model
Pooled OR (95% CI)
value
value
Study number
Cases
Controls
I2 (%)
Allelic genetic model
1.24 (1.13-1.35)
4.76
<0.05
20
8038
8144
66.4
<0.05
East Asian subgroup
1.15 (1.02-1.29)
2.34
<0.05
10
3972
4618
67.9
<0.05
Caucasian subgroup
1.28 (1.09-1.49)
3.07
<0.05
7
2927
2246
65.4
<0.05
Indian subgroup
1.35 (1.12-1.62)
3.13
<0.05
2
905
1042
39.8
0.19
African subgroup
1.84 (0.90-3.74)
1.68
0.09
1
234
238
58.1
0.12
Dominant genetic model
1.27 (1.14-1.42)
4.27
<0.05
20
8038
8144
57.5
<0.05
East Asian subgroup
1.15 (1.00-1.32)
1.91
0.06
10
3972
4618
51.1
<0.05
Caucasian subgroup
1.37 (1.10-1.71)
2.84
<0.05
7
2927
2246
64.8
<0.05
Indian subgroup
1.54 (1.12-2.11)
2.68
<0.05
2
905
1042
61.2
0.08
African subgroup
1.28 (0.77-2.13)
0.97
0.33
1
234
238
0
0.71
Recessive genetic model
1.24 (1.14-1.36)
4.95
<0.05
20
8038
8144
45.5
<0.05
East Asian subgroup
1.17 (1.04-1.31)
2.63
<0.05
10
3972
4618
64.9
<0.05
Caucasian subgroup
1.31 (1.12-1.53)
3.45
<0.05
7
2927
2246
0
0.52
Indian subgroup
1.35 (1.02-1.78)
2.08
<0.05
2
905
1042
0
0.88
African subgroup
18.85 (2.55-139.61)
2.87
<0.05
1
234
238
0
0.34
Homozygous genetic model
1.40 (1.20-1.64)
4.34
<0.05
20
8038
8144
50
<0.05
East Asian subgroup
1.31 (1.04-1.64)
2.3
<0.05
10
3972
4618
64.8
<0.05
Caucasian subgroup
1.47 (1.21-1.79)
3.84
<0.05
7
2927
2246
4.9
0.39
Indian subgroup
1.59 (1.18-2.14)
3.06
<0.05
2
905
1042
0
0.54
African subgroup
13.63 (1.71-108.58)
2.47
<0.05
1
234
238
0
0.36
Heterozygous genetic model
1.20 (1.06-1.35)
2.87
0.004
20
8038
8144
59.5
<0.05
East Asian subgroup
1.08 (0.94-1.24)
1.07
0.29
10
3972
4618
45.4
0.06
Caucasian subgroup
1.32 (1.05-1.66)
2.37
0.02
7
2927
2246
63.9
<0.05
Indian subgroup
1.52 (1.08-2.13)
2.40
0.02
2
905
1042
62.9
0.07
African subgroup
0.63 (0.20-2.07)
0.76
0.45
1
234
238
68.3
0.08
A, mutant type; genetic model: allelic (A vs. G), dominant (AG + AA vs. GG), recessive (AA vs. AG + GG), homozygous (AA vs. GG), and heterozygous (AG vs. GG).
