Expression and Concentration of Matrix Metalloproteinase 9 and Tissue Inhibitor of Matrix Metalloproteinases 1 in Laryngeal Squamous Cell Carcinoma

Figure 3

Immunohistochemical examination: (a) healthy mucosa of the larynx showing no reaction of MMP-9 protein in the matrix and weak expression in the perimatrix mainly in inflammatory cells; (b) strong cytoplasmic expression of MMP-9 in squamous cell carcinomas of the larynx and medium reaction in tumor stroma; (c) TIMP-1 expression in healthy tissue surrounding the tumor showing medium expression in the upper layer of the matrix and strong expression in the perimatrix; and (d) weak TIMP-1 expression in squamous carcinoma of the larynx. Magnification ×200.

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