Research Article
Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population
Table 2
Clinicopathological features of MSI cancers.
| | Characteristics | Defect MMR | Intact MMR | value |
| | Age | | | | | Mean | 51.5 (±14.18) | 55.0 (±15.45) | 0.1 | | ≤57 | 26 (70.3%) | 144 (49.1%) | 0.01 | | ≥57 | 11 (29.7%) | 149 (50.9%) | | Gender | | | | | Female | 10 (27.0%) | 146 (49.8%) | 0.007 | | Male | 27 (73.0%) | 147 (50.2%) | | Tumor site | | | | | Right colon | 23 (62.2%) | 53 (18.1%) | 0.000 | | Left colon | 14 (37.8%) | 240 (81.9%) | | Histologic subtype | | | | | Adenocarcinoma | 30 (81.8%) | 248 (84.6%) | | | Mucinous adenocarcinoma | 6 (16.2%) | 23 (7.8%) | 0.1 | | Others | 1 (2.7%) | 22 (7.5%) | | Histologic grade | | | | | Well | 15 (40.5%) | 208 (71.5%) | 0.000 | | Poor | 22 (59.5%) | 83 (28.5%) | | Vascular invasion | | | | | Yes | 7 (18.9%) | 32 (10.9%) | 0.1 | | No | 30 (81.1%) | 261 (89.1%) | | Perineural invasion | | | | | Yes | 2 (5.7%) | 25 (9.5%) | 0.3 | | No | 33 (94.3%) | 239 (90.5%) | | Family history of cancer | | | | | Yes | 3 (8.1%) | 9 (3.1%) | 0.1 | | No | 34 (91.9%) | 284 (96.9%) | | Tumor stage (T) | | | | | T1 | 0 (0.0%) | 4 (1.3%) | 0.5 | | T2 | 5 (13.5%) | 47 (16.2%) | | T3 | 25 (67.6%) | 173 (59.5%) | | T4 | 7 (18.9%) | 67 (23.0%) | | Distant metastases (M) | | | | | M0 | 36 (97.3%) | 222 (76.8%) | 0.001 | | M1 | 1 (2.7%) | 67 (23.2%) | | Disease stages | | | | | I-II | 28 (75.7%) | 160 (54.6%) | 0.01 | | III-IV | 9 (24.3%) | 133 (45.4%) | | RAS mutation | | | | | Presence | 6 (15.8%) | 32 (84.2%) | 0.09 | | Absence | 12 (15.4%) | 66 (84.6%) |
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MMR: mismatch repair; SD: standard deviation.
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