Research Article
Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population
Table 4
Comparison of clinicopathological characteristics between the right colon and left colon.
| | Characteristics | Right colon | Left colon | value |
| | Age | | | | | Mean (SD) | 51.4 (±15.7) | 55.5 (±15.0) | 0.03 | | ≤57 | 47 (61.8%) | 123 (48.4%) | 0.002 | | ≥57 | 29 (38.2%) | 131 (51.6%) | | Gender | | | | | Female | 28 (36.8%) | 128 (50.4%) | 0.02 | | Male | 48 (63.2%) | 126 (49.6%) | | Histologic subtype | | | | | Adenocarcinoma | 59 (77.6%) | 219 (86.2%) | 0.04 | | Mucinous adenocarcinoma | 12 (15.8%) | 17 (6.7%) | | Others | 5 (6.6%) | 18 (7.1%) | | Histologic grade | | | | | Well | 42 (55.3%) | 131 (51.8%) | 0.05 | | Moderate | 26 (34.2%) | 102 (40.3%) | | Poor | 8 (10.5%) | 20 (7.9%) | | Vascular invasion | | | | | Yes | 14 (18.4%) | 25 (9.8%) | 0.03 | | No | 62 (81.6%) | 229 (90.2%) | | Perineural invasion | | | | | Yes | 7 (9.2%) | 20 (9.0%) | 0.5 | | No | 69 (90.8%) | 203 (91.0%) | | Total lymph node | | | | | Mean (SD) | 20.67 (±11.28) | 17.28 (±8.85) | 0.01 | | | 53 (74.7%) | 82 (46.7%) | 0.000 | | | 18 (25.3%) | 105 (53.3%) | | Family history of cancer | | | | | Yes | 5 (6.6%) | 7 (2.8%) | 0.1 | | No | 71 (93.4%) | 247 (97.2%) | | Tumor stage (T) | | | | | T1 | 1 (1.3%) | 3 (1.2%) | 0.8 | | T2 | 10 (13.2%) | 42 (16.7%) | | T3 | 48 (63.2%) | 150 (59.5%) | | T4 | 17 (22.4%) | 57 (22.6%) | | Distant metastases (M) | | | | | M0 | 68 (91.9%) | 190 (75.4%) | 0.001 | | M1 | 6 (8.1%) | 68 (24.6%) | | Disease stages | | | | | I | 9 (11.8%) | 19 (7.5%) | 0.002 | | II | 45 (59.2%) | 116 (45.7%) | | III | 17 (22.4%) | 56 (22.0%) | | IV | 5 (6.6%) | 63 (24.8%) | | MSI status | | | | | MSI | 23 (30.3%) | 14 (5.5%) | 0.0000 | | MSS | 53 (69.7%) | 240 (94.5%) | | RAS mutation | | | | | Presence | 13 (34.2%) | 25 (65.8%) | 0.4 | | Absence | 22 (28.2%) | 56 (71.8%) |
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SD: standard deviation; LN: lymph node; MSI: microsatellite instability; MSS: microsatellite stable.
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