Research Article
Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population
Table 5
Comparison of clinicopathological parameters between patients less than 57 years old and older patients.
| | Characteristics | ≤57 | ≥57 | value |
| | Gender | | | | | Female | 88 (51.8%) | 68 (42.5%) | 0.05 | | Male | 82 (48.2%) | 92 (57.5%) | | Tumor site | | | | | Right colon | 47 (27.6%) | 29 (18.1%) | 0.02 | | Left colon | 123 (72.4%) | 131 (81.9%) | | Histologic subtype | | | | | Adenocarcinoma | 138 (81.2%) | 140 (87.5%) | 0.07 | | Mucinous adenocarcinoma | 15 (8.8%) | 14 (8.8%) | | Others | 17 (10.0%) | 6 (3.8%) | | Histologic grade | | | | | Well | 88 (52.1%) | 85 (53.1%) | 0.05 | | Moderate | 61 (36.1%) | 67 (41.9%) | | Poor | 20 (11.8%) | 8 (5.0%) | | Vascular invasion | | | | | Yes | 16 (9.4%) | 23 (14.4%) | 0.1 | | No | 154 (90.6%) | 137 (85.6%) | | Perineural invasion | | | | | Yes | 14 (9.1%) | 13 (9.0%) | 0.5 | | No | 140 (90.9%) | 132 (91.0%) | | Total lymph node | | | | | Mean (SD) | 24.5 (±10.30) | 17.9 (±9.06) | 0.000 | | | 68 (90.7%) | 58 (80.6%) | 0.04 | | | 7 (9.3%) | 14 (19.4%) | | Family history of cancer | | | | | Yes | 9 (5.3%) | 3 (1.9%) | 0.02 | | No | 161 (94.7%) | 157 (98.1%) | | Tumor stage (T) | | | | | T1 | 3 (0.0%) | 1 (0.6%) | 0.4 | | T2 | 22 (13.1%) | 30 (18.8%) | | T3 | 101 (60.1%) | 97 (60.6%) | | T4 | 42 (25.0%) | 32 (20.0%) | | Distant metastases (M) | | | | | M0 | 134 (79.8%) | 124 (78.5%) | 0.4 | | M1 | 34 (20.2%) | 34 (21.5%) | | Disease stages | | | | | I | 13 (7.6%) | 15 (9.4%) | 0.6 | | II | 80 (47.1%) | 81 (50.6%) | | III | 42 (24.7%) | 31 (19.4%) | | IV | 35 (20.6%) | 33 (20.6%) | | MSI status | | | | | MSI | 26 (15.3%) | 11 (6.9%) | 0.01 | | MSS | 144 (84.7%) | 149 (93.1%) | | RAS mutation | | | | | Presence | 16 (46.8%) | 22 (57.9%) | 0.3 | | Absence | 36 (42.1%) | 41 (53.2%) |
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SD: standard deviation; LN: lymph node; MSI: microsatellite instability; MSS: microsatellite stable.
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