Research Article
Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population
Table 6
The clinical variables associated with overall survivals in the 330 colon cancer patients.
| Variables | Univariate analysis | Multivariate analysis | Mean OS months (95% CI) | value | Hazard ratio (95% CI) | value |
| Age (yr) | | | | | ≥57 | 79.77 (71.86-87.68) | 0.4 | | | <57 | 75.08 (66.59-83.56) | | | Gender | | | | | Female | 69.09 (60.91-77.28) | 0.003 | 1.52 (1.03-3.08) | 0.03 | Male | 86.19 (78.37-94.01) | Tumor site | | | | | Right side | 97.07 (85.97-108.17) | 0.001 | 1.79 (0.98-3.71) | 0.05 | Left side | 72.72 (66.27-79.16) | Tumor stage | | | | | I-II | 89.48 (82.28-96.68) | 0.000 | 1.49 (1.29-2.82) | 0.001 | III-IV | 63.85 (55.48-72.22) | LNR (mean) | | | | | 1 | 105.50 (100.36-110.64) | 0.03 | 2.04 (0.80-5.18) | 0.1 | 2 | 92.38 (80.66-104.10) | TLN | | | | | ≥12 | 104.77 (96.26-113.27) | 0.6 | | | <12 | 101.72 (95.73-107.71) | Perineural invasion | | | | | Yes | 74.80 (58.63-90.96) | 0.6 | | | No | 82.64 (76.56-88.72) | Vascular invasion | | | | | Yes | 88.47 (73.13-103.81) | 0.1 | | | No | 75.87 (69.73-82.02) | MSI status | | | | | MSI | 109.71 (99.85-119.58) | 0.001 | 0.11 (0.06-1.04) | 0.05 | MSS | 74.08 (68.00-80.16) | RAS mutation | | | | | Presence | 52.52 (40.918-64.133) | 0.5 | | | Absence | 56.75 (42.057-71.452) |
|
|
CI: confidence interval; OS: overall survival; LNR: lymph node ratio; TLN: total lymph node; MSI: microsatellite instability; MSS: microsatellite stable.
|