Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population

Table 6

The clinical variables associated with overall survivals in the 330 colon cancer patients.

Variables	Univariate analysis		Multivariate analysis
	Mean OS months (95% CI)	value	Hazard ratio (95% CI)	value
Age (yr)
≥57	79.77 (71.86-87.68)	0.4
<57	75.08 (66.59-83.56)
Gender
Female	69.09 (60.91-77.28)	0.003	1.52 (1.03-3.08)	0.03
Male	86.19 (78.37-94.01)
Tumor site
Right side	97.07 (85.97-108.17)	0.001	1.79 (0.98-3.71)	0.05
Left side	72.72 (66.27-79.16)
Tumor stage
I-II	89.48 (82.28-96.68)	0.000	1.49 (1.29-2.82)	0.001
III-IV	63.85 (55.48-72.22)
LNR (mean)
1	105.50 (100.36-110.64)	0.03	2.04 (0.80-5.18)	0.1
2	92.38 (80.66-104.10)
TLN
≥12	104.77 (96.26-113.27)	0.6
<12	101.72 (95.73-107.71)
Perineural invasion
Yes	74.80 (58.63-90.96)	0.6
No	82.64 (76.56-88.72)
Vascular invasion
Yes	88.47 (73.13-103.81)	0.1
No	75.87 (69.73-82.02)
MSI status
MSI	109.71 (99.85-119.58)	0.001	0.11 (0.06-1.04)	0.05
MSS	74.08 (68.00-80.16)
RAS mutation
Presence	52.52 (40.918-64.133)	0.5
Absence	56.75 (42.057-71.452)

CI: confidence interval; OS: overall survival; LNR: lymph node ratio; TLN: total lymph node; MSI: microsatellite instability; MSS: microsatellite stable.