Urinary TIMP2 and IGFBP7 Identifies High Risk Patients of Short-Term Progression from Mild and Moderate to Severe Acute Kidney Injury during Septic Shock: A Prospective Cohort Study
Table 1
Clinical characteristics and comparison between patients who did not develop severe AKI (KDIGO<3) and those who developed severe AKI (KDIGO 3) during the 24 hours and 72 hours following inclusion.
Parameter
Global
KDIGO<3 H24
KDIGO 3 H24
value
KDIGO<3 H72
KDIGO 3 or death H72
value
Age (y)
65 (59-75)
65 (55-76)
64 (60-74)
0.93
65 (62-70)
65 (62-71)
0.85
Male ( (%))
67 (60)
41 (61)
26 (58)
0.87
40 (61)
27 (57)
0.70
SAPS II
57 (43-70)
55 (42-64)
64 (51-76)
0.01
52 (47-57)
67 (61-73)
0.001
BMI (kg/m2)
27 (24-32)
28 (24-33)
26 (22-30)
0.21
28 (25-33)
26 (23-33)
0.56
Basal creatinine (μmol/l)
71 (60-92)
76 (61-94)
71 (57-87)
0.37
73 (69-80)
71 (66-79)
0.44
Comorbidity ( (%))
Diabetes
46 (41)
30 (45)
16 (35)
0.43
29 (45)
17 (36)
0.44
Hypertension
56 (50)
34 (51)
22 (49)
0.99
33 (51)
23 (49)
0.99
Cardiovascular disease
22 (20)
14 (21)
8 (18)
0.49
13 (20)
9 (19)
0.99
Any malignancy
34 (30)
17 (25)
17 (38)
0.23
16 (25)
18 (38)
0.15
Origin of sepsis ( (%))
Pulmonary
73 (65)
43 (64)
30 (67)
0.88
43 (64)
30 (64)
0.9
Gastrointestinal
13 (12)
8 (12)
5 (11)
1
7 (11)
6 (13)
0.91
Soft tissue
7 (6)
4 (6)
3 (7)
0.9
5 (6)
2 (4)
0.73
Urinary
7 (6)
6 (9)
1 (2)
0.4
6 (9)
1 (2)
0.25
Other
5 (4)
3 (4)
2 (4)
1
4 (4)
1 (2)
0.82
Baseline MAP (mmHg)
73 (66-86)
74 (67-87)
71 (62-82)
0.15
74 (70-82)
71 (66-76)
0.02
Baseline heart rate (bpm)
105 (90-123)
101 (87-121)
110 (93-127)
0.17
104 (97-109)
111 (100-114)
0.20
Baseline norepinephrine (μg/kg/min)
0.36 (0.16-0.87)
0.27 (0.15-0.45)
0.60 (0.30-1.16)
0.001
0.32 (0.20-0.37)
0.50 (0.29-0.87)
0.03
Fluid administered (between initiation of catecholamines and first urine sample) (ml/kg)
16 (7-25)
15 (5-23)
19 (11-28)
0.01
15 (9-17)
20 (14-25)
0.01
Baseline lactate (mmol/l)
2.6 (1.6-4.2)
2.2 (1.6-3.7)
3.0 (2.0-5.4)
0.03
2.1 (1.8-2.5)
3.5 (2.9-4.4)
0.001
Mechanical ventilation ( (%))
77 (69)
46 (69)
31 (69)
0.85
42 (65)
35 (74)
0.31
Interval between initiation of catecholamines and first urine sample (hours)
2.0 (1.0-4.0)
2.0 (1.0-4.0)
3.0 (1.0-4.0)
0.24
2.0 (2.0-2.7)
3.0 (2.0-3.0)
0.46
Mortality in ICU ( (%))
49 (44)
21 (31)
28 (62)
0.002
18 (28)
31 (66)
0.001
ICU length of stay (days)
6.0 (3-14)
7.0 (4.0-15.7)
5.0 (2.5-12.0)
0.05
8.0 (6.0-10.9)
4.0 (3.0-8.1)
0.09
Renal replacement therapy within 72 hours ( (%))
19 (17)
3 (4)
16 (35)
0.001
2 (3)
17 (36)
0.001
Baseline urine output (ml/kg/h)
0.53 (0.24-1.19)
0.73 (0.40-1.47)
0.31 (0.16-0.64)
0.001
0.71 (0.54-0.95)
0.31 (0.20-0.49)
0.001
Baseline creatinine (μmol/l)
123 (91-174)
114 (87-139)
163 (108-247)
0.001
114 (106-131)
139 (122-170)
0.009
Baseline TIMP2IGFBP7 ((ng/ml)2/1,000)
1.45 (0.58-4.13)
0.93 (0.25-1.59)
3.99 (2.17-9.45)
0.001
1.03 (0.77-1.51)
3.03 (1.81-5.11)
0.001
SAPS II: Simplified Acute Physiology Score 2; MAP: mean arterial pressure; ICU: intensive care unit; H0: time of first urine sample. Basal serum creatinine was defined as the serum creatinine level measured during the 12 months preceding the onset of septic shock. In the absence of a previous serum creatinine assay, basal serum creatinine was estimated according to the KDIGO guideline [3]. All baseline parameters have been recorded at inclusion. Baseline urine output was the volume of urine excreted by hour during the 4 to 6 hours preceding the inclusion.
