Disease Markers

Research Article

Urinary TIMP2 and IGFBP7 Identifies High Risk Patients of Short-Term Progression from Mild and Moderate to Severe Acute Kidney Injury during Septic Shock: A Prospective Cohort Study

Table 2

Stepwise logistic regression risk models for severe AKI 24 hours (H24) or severe AKI and/or death 72 hours (H72) following inclusion.
AKI KDIGO H24
VariableH24 (OR (95% CI)) valueH24 (OR (95% CI)) value
Baseline posology of norepinephrine4.26 (1.16-15.6)0.034.55 (1.43-14.5)0.01
Baseline fluid administered1.02 (0.97-1.06)0.47——
Baseline lactate1.02 (0.80-1.29)0.87——
Baseline creatinine1.01 (1.01-1.02)0.0011.02 (1.01-1.3)0.001
Baseline urine output0.19 (0.05-0.77)0.020.19 (0.05-0.74)0.004
Baseline TIMP2IGFBP71.42 (1.11-1.83)0.0051.42 (1.12-1.81)0.001
Nagelkerke 0.630.64
AKI and/or death H72
VariableH72 (OR (95% CI)) valueH72 (OR (95% CI)) value
Baseline mean arterial pressure0.97 (0.94-1.01)0.18——
Baseline posology of norepinephrine1.93 (0.70-5.32)0.2——
Baseline fluid administered1.03 (0.99-1.07)0.12——
Baseline lactate1.22 (0.98-1.52)0.08——
Baseline creatinine1.01 (1.00-1.02)0.041.01 (0.99-1.01)0.06
Baseline urine output0.65 (0.30-1.39)0.27——
Baseline TIMP2IGFBP71.21 (1.00-1.45)0.041.31 (1.12-1.53)0.001
Nagelkerke 0.450.29