Disease Markers / 2019 / Article / Tab 2

Research Article

Investigation of Key Genes and Pathways in Inhibition of Oxycodone on Vincristine-Induced Microglia Activation by Using Bioinformatics Analysis

Table 2

Gene ontology analysis of differentially expressed genes.

CategoryTermCount valueGenes

GOTERM_MF_DIRECTGO:0048248—CXCR3 chemokine receptor binding32.16-05CXCL9, PF4, CXCL10
GOTERM_BP_DIRECTGO:0030816—positive regulation of cAMP metabolic process31.10-04CXCL9, PF4, CXCL10
GOTERM_BP_DIRECTGO:0043950—positive regulation of cAMP-mediated signaling32.21-04CXCL9, PF4, CXCL10
GOTERM_BP_DIRECTGO:0002690—positive regulation of leukocyte chemotaxis32.55-04CXCL9, PF4, CXCL10
GOTERM_BP_DIRECTGO:0042127—regulation of cell proliferation54.92-04SFRP2, PLA2G2A, CXCL9, PF4, CXCL10
GOTERM_MF_DIRECTGO:0008009—chemokine activity30.001322CXCL9, PF4, CXCL10
GOTERM_BP_DIRECTGO:0070098—chemokine-mediated signaling pathway30.003717CXCL9, PF4, CXCL10
GOTERM_BP_DIRECTGO:0032496—response to lipopolysaccharide40.009824CXCL9, PF4, GJB6, CXCL10
GOTERM_BP_DIRECTGO:0006954—inflammatory response40.0115218CXCL9, CRH, PF4, CXCL10
GOTERM_BP_DIRECTGO:0006955—immune response30.0673817CXCL9, PF4, CXCL10
GOTERM_BP_DIRECTGO:0007186—G protein-coupled receptor signaling pathway50.4113867SFRP2, CXCL9, PF4, GNG11, CXCL10
GOTERM_CC_DIRECTGO.0005833—hemoglobin complex20.3525113Hba2, Hbb