Investigating the Protein Signature of Adamantinomatous Craniopharyngioma Pediatric Brain Tumor Tissue: Towards the Comprehension of Its Aggressive Behavior
Table 3
Top 25 pathways’ list resulting from REACTOME database pathway overrepresentation analysis.
Pathway name
# entities found
# entities total
Entity ratio
Entity value
Entity FDR
# reactions found
# reactions total
Reaction ratio
Neutrophil degranulation
84
480
0.034
10
10
Platelet degranulation
40
137
0.010
6
11
Platelet activation, signaling, and aggregation
47
293
0.021
53
114
Response to elevated platelet cytosolic Ca2+
40
144
0.010
6
14
Innate immune system
134
1302
0.093
243
651
Immune system
170
2641
0.189
415
1493
Hemostasis
75
812
0.058
129
327
Regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor-binding proteins (IGFBPs)
27
127
0.009
3
14
Posttranslational protein phosphorylation
25
109
0.008
1
1
Vesicle-mediated transport
63
820
0.059
160
251
Cellular responses to stress
46
512
0.037
67
184
Detoxification of reactive oxygen species
16
65
0.005
21
34
Regulation of complement cascade
22
139
0.010
40
42
Metabolism of proteins
125
2342
0.167
269
883
Gene and protein expression by JAK-STAT signaling after interleukin-12 stimulation
