Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients

Table 3

Results of crude and age-adjusted univariable Cox proportional hazard regression for death.

Parameter	Cox proportional hazard—crude analysis					Cox proportional hazard—age adjusted
	HR	95% CI				HR	95% CI
years	2.74	1.69–4.43	<0.001	1.73	0.19	—	—	—	—	—
Female vs. male	1.67	1.05–2.65	<0.05	0.33	0.57	1.27	0.78–2.07	0.34	0.09	0.76
Diabetes	1.79	1.15–2.78	<0.05	1.68	0.19	1.57	1.01–2.45	<0.05	1.11	0.29
Hypertension	0.87	0.48–1.58	0.65	1.65	0.20	0.71	0.38–1.29	0.26	1.40	0.24
Atrial fibrillation	1.68	1.07–2.64	<0.05	0.15	0.70	1.22	0.76–1.96	0.40	0.34	0.55
Ischemic heart disease	1.52	0.96–2.41	0.08	0.02	0.90	1.32	0.83–2.11	0.24	0.01	0.92
Valvular diseases	1.67	0.88–3.17	0.12	0.29	0.59	1.42	0.75–2.71	0.28	0.44	0.51
Previous stroke	1.14	0.67–1.92	0.63	1.59	0.21	0.99	0.59–1.69	0.99	1.57	0.21
Hypercholesterolemia	0.72	0.43–1.19	0.20	0.20	0.65	0.76	0.46–1.26	0.29	0.21	0.64
pg/mL	1.64	1.01–2.69	<0.05	0.18	0.67	1.41	0.86–2.32	0.17	0.50	0.48
pg/mL	0.89	0.57–1.39	0.63	0.12	0.73	0.92	0.59–1.44	0.72	0.04	0.84
mL/min/1. 73 m^2	1.71	1.09–2.66	<0.05	0.05	0.82	1.26	0.79–2.01	0.33	0.26	0.61
ng/mL	2.45	1.41–4.25	<0.01	0.40	0.52	2.32	1.33–4.02	<0.01	0.26	0.61
mg/L	1.47	0.91–2.38	0.12	0.03	0.86	1.25	0.77–2.03	0.37	0.01	0.97
Modified Rankin scale (mRS) at	3.31	1.81–6.03	<0.001	2.69	0.10	3.20	1.76–5.85	<0.001	2.25	0.13
mRS at	7.64	4.87–12.01	<0.001	8.55	<0.01	6.47	3.99–10.49	<0.001	6.81	<0.01
mRS at with time	1.05	1.01–1.09	<0.05	—	—	1.04	1.01–1.09	<0.05	—	—
25-OH-D 20–29.9 ng/mL	2.37	1.15–4.88	<0.05	2.41	0.49	2.29	1.11–4.71	<0.05	1.79	0.62
25-OH-D 10–19.9 ng/mL	5.38	2.32–12.47	<0.001			5.01	2.15–11.67	<0.001
ng/mL	11.99	5.23–27.51	<0.001			9.11	3.92–21.19	<0.001
NIHSS-I at admission (pts)	1.10	1.06–1.14	<0.001	0.33	0.56	1.09	1.04–1.13	<0.001	0.19	0.67