Biological Analysis of Gene Expression and Clinical Variables Suggest FZD1 as a Novel Biomarker for Patients with Kashin-Beck Disease, an Endemic Osteoarthritis in China

Table 2

Univariate analysis of categorical variables in clinical parameters and general information between KBD grades I and II.

Variables	Grade I		Grade II				OR
	+	−	+	−
Phalanges tuberositas	23	7	47	3	3.688	0.055	4.768 (1.13 ± 20.15)
Brachydactylia	3	27	49	1	63.82	0.0001	441.0 (43.7 ± 4449)
Deformity of elbow	23	7	47	3	3.688	0.055	4.768 (1.13 ± 20.15)
Deformity of knee	11	19	35	15	8.525	0.004	4.030 (1.54 ± 10.50)
Dyskinesia in joints of wrist	22	8	46	4	3.765	0.052	4.182 (1.13 ± 15.39)
Dyskinesia in joints of elbow	24	6	49	1	5.521	0.019	12.25 (1.39 ± 107.5)
Dyskinesia in joints of shoulder	1	29	11	39	3.765	0.052	8.179 (0.99 ± 66.98)
Dyskinesia in joints of knee	11	19	40	10	15.23	0.0001	6.909 (2.50 ± 19.07)
Dyskinesia in joints of ankle	26	4	48	2	1.201	0.273	3.692 (0.63 ± 21.53)
Fracture	2	28	6	44	0.148	0.700	1.909 (0.36 ± 10.13)
Blurred vision	18	12	41	9	4.688	0.030	3.037 (1.08 ± 8.479)
Hearing disorder	13	17	19	31	0.222	0.637	0.081 (0.32 ± 2.012)
Diarrhea	7	23	4	46	3.717	0.054	0.286 (0.07 ± 1.077)
Astriction	2	28	0	50	—	0.138	0.933 (0.84 ± 1.027)
Senile wart	7	23	10	40	0.124	0.724	0.821 (0.27 ± 2.452)
Decayed tooth	28	2	39	11	2.210	0.137	0.253 (0.05 ± 1.233)
Smoke	8	22	12	38	0.071	0.790	0.868 (0.31 ± 2.450)
Alcohol consumption	0	30	4	46	—	0.291	1.087 (1.01 ± 1.180)
Patients with KBD in other family members	10	20	34	16	9.104	0.003	4.250 (1.62 ± 11.14)

OR: odds ratios.