Disease Markers

Research Article

Exploring the Diagnostic Potential of Serum Golgi Protein 73 for Hepatic Necroinflammation and Fibrosis in Chronic HCV Infection with Different Stages of Liver Injuries

Table 1

Demographic and clinical characteristics of different states of chronic HCV infection in Cohort A.


Parameters	Cohort A			value
Parameters	Precirrhotic CHC ()	Compensated LC ()	Decompensated LC ()	value

Age (y, )				<0.001
Gender (M/F)	45/51	11/24	17/26	0.268
BMI (kg/m², )				0.146
HCV genotype (1b/2a/unknown)	45/37/14	17/9/9	11/11/21	0.001
HCV RNA (+/−)	88/8	33/2	37/6	0.417
TBIL (μmol/L)	12.4 (8.9, 16.2)	15.5 (10.0, 24.6)	18.2 (15.2, 22.3)	<0.001
ALT (U/L)	45.5 (25.0, 84.8)	42.0 (28.0, 73.0)	38.0 (22.0, 61.0)	0.347
AST (U/L)	37.5 (25.0, 57.8)	66.0 (46.0, 90.0)	40.0 (34.0, 75.0)	0.001
GGT (U/L)	26.0 (16.3, 52.5)	57.0 (34.0, 100)	32.0 (20.0, 48.0)	<0.001
ALB (g/L, )				<0.001
GLB (g/L)	30.0 (26.0, 32.3)	35.0 (30.0, 39.0)	31.0 (25.0, 36.0)	0.001
PA (mg/L, )				<0.001
RBC (10¹²/L, )				<0.001
PLT (10⁹/L, )				<0.001
PT (s, )	11.0 (10.5, 11.5)	1.24 (11.6, 13.1)	13.3 (12.4, 14.1)	<0.001
GP73 (ng/mL, )				<0.001
Necroinflammation activity grade (G: 0-1/2/3/4)	50/40/6/0	-/8/1/-	—	—
Fibrosis stage (F: 0-1/2/3/4)	35/30/31/0	0/0/0/35	0/0/0/43	—

Continuous variables were expressed as (SD) or median and interquartile range (IQR). BMI: body mass index; HCV: hepatitis C virus; TBIL: total bilirubin; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: gamma glutamyltransferase; ALB: albumin; GLB: globulin; PA: prealbumin; RBC: red blood cell; PLT: platelet; PT: prothrombin time; GP73: Golgi protein 73.