Exploring the Diagnostic Potential of Serum Golgi Protein 73 for Hepatic Necroinflammation and Fibrosis in Chronic HCV Infection with Different Stages of Liver Injuries
Table 5
Diagnostic values of GP73, APRI, and FIB-4 for advanced fibrosis () and cirrhosis ().
Parameters
AUC
95% CI
Cutoff value
Sensitivity (%)
Specificity (%)
PPV (%)
NPV (%)
value
(Cohort A)
GP73
0.761
(0.678, 0.831)
63.89
81.82
58.46
66.7
76.0
<0.0001
APRI
0.796
(0.717, 0.861)
1.5
45.45
84.62
75.0
60.4
<0.0001
FIB-4
0.848
(0.775, 0.905)
3.25
59.09
87.69
83.0
67.9
<0.0001
(Cohort A)
GP73
0.779
(0.698, 0.847)
64.96
91.43
52.08
41.0
94.3
<0.0001
APRI
0.836
(0.761, 0.895)
2.0
51.43
90.62
66.7
83.7
<0.0001
FIB-4
0.904
(0.840, 0.948)
3.25
85.71
84.37
66.7
94.2
<0.0001
(Cohort B)
GP73
0.709
(0.619, 0.788)
93.74
71.43
55.66
17.5
93.7
0.0037
APRI
0.839
(0.761, 0.900)
1.5
57.14
95.24
61.5
94.3
<0.0001
FIB-4
0.829
(0.749, 0.891)
3.25
57.14
91.43
47.1
94.1
<0.0001
GP73: Golgi protein 73; APRI: AST-to-platelet ratio index; FIB-4: fibrosis index based on four factors; AUC: area under the curve; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value.
