Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population

Table 3

Distribution of SNPs in AXIN1 between patients and controls as well as their association with bladder cancer risk.

Model	Genotype	Patients	Controls	Logistic regression
		(%)	(%)	OR (95% CI)	value
rs12921862
Codominant	CC	205 (64.9%)	375 (89.5%)	1.00
	CA	106 (33.5%)	37 (8.8%)	5.24 (3.47-7.91)	<0.001
	AA	5 (1.6%)	7 (1.7%)	1.31 (0.41-4.17)
Dominant	CC	205 (64.9%)	375 (89.5%)	1.00
	CA/AA	111 (35.1%)	44 (10.5%)	4.61 (3.13-6.81)	<0.001
Recessive	CC/CA	311 (98.4%)	412 (98.3%)	1.00
	AA	5 (1.6%)	7 (1.7%)	0.95 (0.30-3.01)	0.93
Overdominant	CC/AA	210 (66.5%)	382 (91.2%)	1.00
	CA	106 (33.5%)	37 (8.8%)	5.21 (3.46-7.86)	<0.001
Allele	C	516 (81.6%)	787 (93.9%)	1.00
	A	116 (18.4%)	51 (6.1%)	3.45 (2.44-5.00)	<0.001
rs1805105
Codominant	TT	168 (53.5%)	255 (60.9%)	1.00
	TC	125 (39.8%)	136 (32.5%)	1.40 (1.02-1.90)	0.11
	CC	21 (6.7%)	28 (6.7%)	1.14 (0.63-2.07)
Dominant	TT	168 (53.5%)	255 (60.9%)	1.00
	TC/CC	146 (46.5%)	164 (39.1%)	1.35 (1.00-1.82)	0.046
Recessive	TT/TC	293 (93.3%)	391 (93.3%)	1.00
	CC	21 (6.7%)	28 (6.7%)	1.00 (0.56-1.80)	1
Overdominant	TT/CC	189 (60.2%)	283 (67.5%)	1.00
	TC	125 (39.8%)	136 (32.5%)	1.38 (1.01-1.87)	0.04
Allele	T	461 (73.4%)	646 (77.1%)	1.00
	C	167 (26.6%)	192 (22.9%)	1.22 (0.96-1.55)	0.11
rs370681
Codominant	CC	114 (37.9%)	204 (48.7%)	1.00
	CT	152 (50.5%)	190 (45.4%)	1.43 (1.05-1.96)	0.002
	TT	35 (11.6%)	25 (6%)	2.51 (1.43-4.40)
Dominant	CC	114 (37.9%)	204 (48.7%)	1.00
	CT/TT	187 (62.1%)	215 (51.3%)	1.56 (1.15-2.10)	0.004
Recessive	CC/CT	266 (88.4%)	394 (94%)	1.00
	TT	35 (11.6%)	25 (6%)	2.07 (1.21-3.55)	0.01
Overdominant	CC/TT	149 (49.5%)	229 (54.6%)	1.00
	CT	152 (50.5%)	190 (45.4%)	1.23 (0.91-1.65)	0.17
Allele	C	380 (63.1%)	598 (71.4%)	1.00
	T	222 (36.9%)	240 (28.6%)	1.46 (1.16-1.82)	0.001

Boldfaced values indicate a significant difference at the 5% level. OR: odds ratio; CI: confidence interval.