Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population
Table 4
Distribution of SNPs in AXIN1 between patients’ characteristics and their association with bladder cancer risk.
Characteristics
rs12921862
rs1805105
rs370681
Genotype
value
Genotype
value
Genotype
value
CC
CA/AA
TT
TC/CC
CC
CT/TT
Age
≤64 years old
102 (70.8%)
42 (29.2%)
0.04
85 (59%)
59 (41%)
0.10
56 (40.3%)
83 (59.7%)
0.83
>64 years old
103 (59.9%)
69 (40.1%)
83 (48.8%)
87 (51.2%)
58 (35.8%)
104 (64.2%)
Sex
Male
164 (65.9%)
85 (34.1%)
0.77
128 (51.6%)
120 (48.4%)
0.47
88 (37.5%)
147 (62.5%)
0.96
Female
41 (61.2%)
26 (38.8%)
40 (60.6%)
26 (39.4%)
26 (39.4%)
40 (60.6%)
Smoke
Smoker
111 (68.1%)
52 (31.9%)
0.4
80 (49.4%)
82 (50.6%)
0.25
58 (37.7%)
96 (62.3%)
0.90
Nonsmoker
94 (61.4%)
59 (38.6%)
88 (57.9%)
64 (42.1%)
56 (38.1%)
91 (61.9%)
Tumor stage
MIBC
98 (65.3%)
52 (34.7%)
0.94
74 (49.7%)
75 (50.3%)
0.97
48 (33.1%)
97 (66.9%)
0.44
NMIBC
107 (64.5%)
59 (35.5%)
94 (57%)
71 (43%)
66 (42.3%)
90 (57.7%)
Tumor grade
High grade
120 (65.9%)
62 (34.1%)
0.49
87 (48.3%)
93 (51.7%)
0.18
56 (32%)
119 (68%)
0.04
Low grade
85 (63.4%)
49 (36.6%)
81 (60.5%)
53 (39.5%)
58 (46%)
68 (54%)
Recurrence
Recurrent
59 (63.4%)
34 (36.6%)
0.84
50 (53.8%)
43 (46.2%)
0.97
32 (36%)
57 (64%)
0.40
Nonrecurrent
146 (65.5%)
77 (34.5%)
118 (53.4%)
103 (46.6%)
82 (38.7%)
130 (61.3%)
Metastasis
Metastatic
31 (62%)
19 (38%)
0.68
24 (49%)
25 (51%)
0.70
19 (40.4%)
28 (59.6%)
0.07
Nonmetastatic
174 (65.4%)
92 (34.6%)
144 (54.3%)
121 (45.7%)
94 (37.1%)
159 (62.9%)
Italic values indicate a significant difference at the 5% level. Adjusted by age, sex, smoking status, tumor stage, tumor grade, recurrence status, and metastasis status.
