Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population

Table 5

Association between SNPs in AXIN1 and overall survival for patients with MIBC or NMIBC.

SNP/genotype	MIBC			NMIBC
	Alive/dead	HR (95% CI)	value	Alive/dead	HR (95% CI)	value
rs12921862
CC	75/22			96/12
CA	34/13			58/1
AA	2/3			0/0
Codominant		1.41 (0.83-2.42)	0.21		0.10 (0.01-0.84)	0.03
Dominant		1.45 (0.74-2.88)	0.28		0.10 (0.01-0.84)	0.03
Recessive		1.94 (0.53-6.89)	0.32		NA	NA
rs1805105
TT	54/19			89/6
TC	46/16			56/7
CC	11/2			8/0
Codominant		1.40 (0.71-2.76)	0.34		0.97 (0.34-2.72)	0.95
Dominant		1.21 (0.58-2.54)	0.62		1.12 (0.35-3.62)	0.85
Recessive		4.28 (0.88-20.88)	0.07		0.00 (0.00-NA)	0.99
rs370681
CC	37/10			60/7
CT	55/23			69/5
TT	16/3			16/0
Codominant		1.30 (0.72-2.34)	0.38		0.54 (0.19-1.54)	0.25
Dominant		1.76 (0.76-4.06)	0.18		0.60 (0.18-1.97)	0.40
Recessive		0.82 (0.21-3.17)	0.77		0.00 (0.00-NA)	0.99

Italic values indicate a significant difference at the 5% level. Adjusted by age, sex, smoking status, tumor stage, tumor grade, recurrence status, and metastasis status. HR: hazard ratio; CI: confidence interval.