Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals
Table 2
The association between the ADRB3 genotype and the risk of NAFLD in the overall study population.
Bivariable
Multivariable
OR [95% CI]
value
OR [95% CI]
value
ADRB3 rs4994 genotype
T/T
1
—
1
—
T/C
1.28 [0.84-1.96]
0.26
1.53 [0.91-2.57]
0.11
C/C
1.95 [0.77-4.93]
0.16
2.31 [0.67-8.01]
0.19
Age
0.98 [0.96-0.99]
<0.01
0.97 [0.95-0.99]
<0.01
Gender
Male
1
—
Female
0.57 [0.37-0.87]
<0.01
BMI
1.55 [1.41-1.71]
<0.01
1.42 [1.27-1.58]
<0.01
HOMA-IR
2.22 [1.75-2.81]
<0.01
1.73 [1.35-2.23]
<0.01
Diabetes
Absent
1
—
Present
2.54 [1.52-4.25]
<0.01
Dyslipidemia
Absent
1
—
1
—
Present
4.21 [2.58-6.87]
<0.01
3.69 [2.06-6.61]
<0.01
Alcohol intake
Nondrinker
1
—
Drinker
0.97 [0.65-1.45]
0.88
Smoking status
Never smoker
1
—
Ever smoker
1.58 [1.05-2.38]
0.03
ADRB3: beta-3-adrenergic receptor; NAFLD: nonalcoholic fatty liver disease; BMI: body mass index; OR: odds ratio; CI: confidence interval. Analyzed using a logistic regression analysis.
