Disease Markers / 2019 / Article / Tab 2

Research Article

Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

Table 2

The association between the ADRB3 genotype and the risk of NAFLD in the overall study population.

BivariableMultivariable
OR [95% CI] valueOR [95% CI] value

ADRB3 rs4994 genotype
 T/T11
 T/C1.28 [0.84-1.96]0.261.53 [0.91-2.57]0.11
 C/C1.95 [0.77-4.93]0.162.31 [0.67-8.01]0.19
Age0.98 [0.96-0.99]<0.010.97 [0.95-0.99]<0.01
Gender
 Male1
 Female0.57 [0.37-0.87]<0.01
BMI1.55 [1.41-1.71]<0.011.42 [1.27-1.58]<0.01
HOMA-IR2.22 [1.75-2.81]<0.011.73 [1.35-2.23]<0.01
Diabetes
 Absent1
 Present2.54 [1.52-4.25]<0.01
Dyslipidemia
 Absent11
 Present4.21 [2.58-6.87]<0.013.69 [2.06-6.61]<0.01
Alcohol intake
 Nondrinker1
 Drinker0.97 [0.65-1.45]0.88
Smoking status
 Never smoker1
 Ever smoker1.58 [1.05-2.38]0.03

ADRB3: beta-3-adrenergic receptor; NAFLD: nonalcoholic fatty liver disease; BMI: body mass index; OR: odds ratio; CI: confidence interval. Analyzed using a logistic regression analysis.

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